{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T05:21:03Z","timestamp":1787721663823,"version":"build-2784847793"},"reference-count":57,"publisher":"Wiley","issue":"32","license":[{"start":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T00:00:00Z","timestamp":1784937600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T00:00:00Z","timestamp":1784937600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Burn wound infections, caused by\n                    <jats:italic>Staphylococcus aureus (S. aureus)<\/jats:italic>\n                    and\n                    <jats:italic>Pseudomonas aeruginosa (P. aeruginosa)<\/jats:italic>\n                    , remain a major clinical challenge, delaying healing and increasing the risk of mortality. Gentamicin sulfate (GEN) is a broad\u2010spectrum antibiotic widely used for infection control. However, conventional GEN\u2010loaded hydrogels often suffer from burst release and inadequate mechanical strength for sustained wound coverage. Here, we report GEN\u2010loaded (0.11\u20130.72 w\/v%) supramolecular hybrid hydrogels (GEN\u2010SHHs) in which GEN acts in a dual role as both an antimicrobial and a dynamic physical crosslinker through cucurbit[7]uril (CB[7]) host\u2013guest interactions within a clay\u2010reinforced hydrogel network. This polymer network gels within 5 s and achieves an exceptional elastic modulus (up to \u223c270\u00a0kPa), the highest reported for CB[7]\u2010based or antibiotic\u2010crosslinked hydrogels. This integrated design achieves sustained GEN release for 14 days at concentrations above the minimum inhibitory and bactericidal thresholds for\n                    <jats:italic>S. aureus<\/jats:italic>\n                    and\n                    <jats:italic>P. aeruginosa<\/jats:italic>\n                    , yielding complete eradication (&gt;99.999%) at GEN loadings \u22650.44 w\/v%. Prolonged antimicrobial efficacy is further confirmed by persistent inhibition zones over two weeks. GEN\u2010SHHs also maintain high cytocompatibility (&gt;94% viability) with human dermal fibroblasts (HDFs) and epidermal keratinocytes (HEKs). These results establish GEN\u2011SHHs combining dynamic bonding, high stiffness, and durable antimicrobial performance for advanced infection\u2010resistant wound dressings.\n                  <\/jats:p>","DOI":"10.1002\/adhm.71477","type":"journal-article","created":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T10:54:57Z","timestamp":1784976897000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Gentamicin\u2010Linked Supramolecular Hybrid Hydrogels: Mechanically Robust Cucurbit[7]Uril\u2010Based Networks for Prolonged Infection Control"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5880-0049","authenticated-orcid":false,"given":"A. Aslihan","family":"Gokaltun","sequence":"first","affiliation":[{"name":"Center For Engineering in Medicine and Surgery, Massachusetts General Hospital, Department of Surgery Harvard Medical School  Boston Massachusetts USA"},{"name":"Shriners Children's Boston  Boston Massachusetts USA"},{"name":"Department of Chemical and Biological Engineering Tufts University  Medford Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dinesh","family":"Shrestha","sequence":"additional","affiliation":[{"name":"Center For Engineering in Medicine and Surgery, Massachusetts General Hospital, Department of Surgery Harvard Medical School  Boston Massachusetts USA"},{"name":"Shriners Children's Boston  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Dos Anjos","sequence":"additional","affiliation":[{"name":"Wellman Center for Photomedicine, Massachusetts General Hospital, Department of Dermatology Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nafiseh","family":"Khoshnevisan","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biological Engineering Tufts University  Medford Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianhong","family":"Dai","sequence":"additional","affiliation":[{"name":"Wellman Center for Photomedicine, Massachusetts General Hospital, Department of Dermatology Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4704-1542","authenticated-orcid":false,"given":"Ayse","family":"Asatekin","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biological Engineering Tufts University  Medford Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O. 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