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However, its biomedical applications are constrained by suboptimal therapeutic efficacy, leakage of metal ions from inducing agents, and the absence of noninvasive evaluation methods. In this study, we aimed to develop a self\u2010reducing nano\u2010theranostic agent (Fe@AP\u2010SAS\/RGD, FASR) for tumor\u2010targeted ferroptosis therapy and conducted real\u2010time magnetic resonance imaging(MRI) to monitor ferroptosis by encapsulating iron oxide particles in natural apple pectin (AP). In a weakly acidic tumor microenvironment, the strong reducing ability of AP accelerated the transformation of Fe\n                    <jats:sup>3+<\/jats:sup>\n                    within FASR into highly active Fe\n                    <jats:sup>2+<\/jats:sup>\n                    . Subsequently, the concentration of Fe\n                    <jats:sup>2+<\/jats:sup>\n                    increased and boosted the antitumor effect of ferroptosis. Notably, MRI of prostate cancer mouse models after intravenous injection of FASR NPs at varying doses revealed that the T\n                    <jats:sub>2<\/jats:sub>\n                    value decreased at the tumor sites and exhibited a linear correlation with the changes in ferroptosis hallmark markers, tumor weight, and volume after treatment. These findings demonstrate the capacity of T\n                    <jats:sub>2<\/jats:sub>\n                    mapping to quantitatively evaluate ferroptosis efficacy. This study not only introduced a tumor\u2010targeted and self\u2010reducing strategy to amplify ferroptosis but also pioneered a novel pathway for noninvasive imaging and monitoring of ferroptosis treatment processes within live tumors.\n                  <\/jats:p>","DOI":"10.1002\/adhm.71479","type":"journal-article","created":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T10:51:41Z","timestamp":1784976701000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["MRI\u2010Based Quantitative Evaluation of Tumor Ferroptosis Mediated by A Novel Self\u2010Reducing Nano\u2010Prodrug"],"prefix":"10.1002","volume":"15","author":[{"given":"Shuang","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Radiology The Second Hospital of Tianjin Medical University  Tianjin People's Republic of 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