{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T05:20:32Z","timestamp":1787721632826,"version":"build-2784847793"},"reference-count":50,"publisher":"Wiley","issue":"32","license":[{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32571525"],"award-info":[{"award-number":["32571525"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52425305"],"award-info":[{"award-number":["52425305"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100022963","name":"Key Research and Development Program of Zhejiang Province","doi-asserted-by":"publisher","award":["2025C02134"],"award-info":[{"award-number":["2025C02134"]}],"id":[{"id":"10.13039\/100022963","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Effective hemorrhage control remains an important unmet need in trauma care and emergency medicine. Therefore, it is essential to achieve rapid and effective hemostasis. Bioadhesives offer an attractive approach to wound sealing, achieving simultaneous leakage prevention, mechanical support, and hemostasis. However, available bioadhesives are limited in clinical applications by weak mechanical strength, insufficient biocompatibility, and strict storage condition. In this study, a thrombin\u2010independent fibrinogen\u2010based hydrogel was developed, featuring rapid gelation, robust mechanical strength, strong tissue adhesion, and excellent shelf stability. This hydrogel is prepared from knob\u2010peptide\u2010grafted gelatin methacryloyl (GMK) and fibrinogen methacryloyl (FM). GMK\/FM hydrogel can quickly form the knob\u2010hole crosslinking and then be reinforced through photo\u2010crosslinking. Compared with clinical standard\u2010of\u2010care fibrin glue, GMK\/FM hydrogel demonstrates comparably rapid gelation (&lt;\u00a02\u00a0s), alongside enhanced mechanical strength, tissue adhesion and storage stability (4 weeks at room temperature). In rat severe hemorrhage models of liver and abdominal aorta, GMK\/FM hydrogel decreased hemostatic time and blood loss remarkably. It demonstrates exceptional hemostatic performance, outstanding biocompatibility, and storage stability, holding significant promise for clinical applications and emergency uses.<\/jats:p>","DOI":"10.1002\/adhm.71483","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T08:57:59Z","timestamp":1785229079000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Shelf\u2010Stable, Rapid\u2010Gelling, and Robust Thrombin\u2010Independent Fibrinogen\u2010Based Hydrogels for Massive Hemorrhage Control"],"prefix":"10.1002","volume":"15","author":[{"given":"Yihang","family":"Ding","sequence":"first","affiliation":[{"name":"MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaodi","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of Zhejiang Province Department of Hepatobiliary and Pancreatic Surgery School of Medicine The Second Affiliated Hospital Zhejiang University  Hangzhou China"},{"name":"Department of Plastic Surgery School of Medicine The Second Affiliated Hospital Zhejiang University  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xizhuo","family":"Jing","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruifen","family":"Yang","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiliang","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Ultrasonography Shulan (Hangzhou) Hospital, Shulan International Medical College Zhejiang Shuren University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisha","family":"Yu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of Zhejiang Province Department of Hepatobiliary and Pancreatic Surgery School of Medicine The Second Affiliated Hospital Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7990-2856","authenticated-orcid":false,"given":"Zhengwei","family":"Mao","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Zhejiang University  Hangzhou China"},{"name":"Key Laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of Zhejiang Province Department of Hepatobiliary and Pancreatic Surgery School of Medicine The Second Affiliated Hospital Zhejiang University  Hangzhou China"},{"name":"State Key Laboratory of Transvascular Implantation Devices  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,28]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41570\u2010021\u201000323\u2010z"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2016.10.037"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201700859"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41578\u2010019\u20100171\u20107"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.0c00798"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/1553350619889274"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abf9635"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colcom.2024.100809"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2015.05.022"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202111465"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/bjs\/znad361"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202006362"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/EXP.20230176"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.3c00380"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201103794"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0007\u20101226(90)90044\u2010Z"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2020.09.006"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/rb\/rbx025"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/rb\/rbac021"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202501016"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102012\u201009\u2010306639"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102005\u201005\u20102039"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/cjoc.202300380"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538\u20107836.2007.02485.x"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202406909"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3010383"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202003528"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2021.112352"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201901693"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1039\/C3SM52272E"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202308171"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2025.123602"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2016.04.041"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsif.2008.0327"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2011.09.079"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2020.116067"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph15020171"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2017.09.002"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.86930"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202009189"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201035907\u20104"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202405290"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.5c15336"},{"key":"e_1_2_9_45_1","first-page":"176","article-title":"Experimental Evaluation of Chitosan Membrane and Collagen Sponge (TachoSil\u00ae) as Sealants in Cardiovascular Surgery","volume":"37","author":"dos Santos R. N.","year":"2022","journal-title":"Brazilian Journal of Cardiovascular Surgery"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2TB02371G"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.3390\/ma9100797"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102009\u201011\u2010251801"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adh4327"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41551\u2010021\u201000769\u2010y"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abh2857"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.71483","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adhm.71483","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.71483","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T04:51:14Z","timestamp":1787719874000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.71483"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,28]]},"references-count":50,"journal-issue":{"issue":"32","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1002\/adhm.71483"],"URL":"https:\/\/doi.org\/10.1002\/adhm.71483","archive":["Portico"],"relation":{},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,28]]},"assertion":[{"value":"2026-03-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71483"}}