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Sulforaphene (SE) exerts antiobesity effects but suffers from poor water solubility, low bioavailability, and flawed traditional nanocarrier fabrication. Herein, we report an optimized 3D obstacle Tesla valve micromixer (3D\u2010OTVM) platform. This system enables uniform mixing and controlled shear force, overcoming traditional fabrication bottlenecks. Using this platform, we constructed M(\u03b1\u2010Lac\u2010SE) nanomicelles via controlled hydrolysis of \u03b1\u2010lactalbumin, and demonstrated that M(\u03b1\u2010Lac\u2010SE) exerts synergistic lipid\u2010lowering effects by activating white adipose beiging alongside inhibiting adipogenesis. Notably, an 8\u2010week head\u2010to\u2010head comparison in high\u2010fat diet (HFD)\u2010induced obese mice showed that M(\u03b1\u2010Lac\u2010SE) produced stronger fat\u2010reducing effects than semaglutide under the present experimental conditions, while inducing markedly lower kaolin intake\u2010associated pica behavior, a surrogate indicator of nausea\u2010like gastrointestinal discomfort. In vitro, M(\u03b1\u2010Lac\u2010SE) entered adipocytes via caveolin\/lipid raft\u2010mediated endocytosis with lysosomal escape, reducing lipid droplets by over 52%. In HFD\u2010induced obese mice, M(\u03b1\u2010Lac\u2010SE) decreased body weight by 11.9% after 8 weeks of treatment, improved dyslipidemia and hepatic lipid accumulation, and showed no obvious abnormalities in serum biochemical indicators or major\u2010organ histopathology. This work breaks delivery bottlenecks and provides a precise nanodelivery\u2010based strategy for obesity intervention.<\/jats:p>","DOI":"10.1002\/adhm.71486","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T07:17:06Z","timestamp":1785223026000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Novel Microfluidic Strategy for the Fabrication of \u03b1\u2010Lactalbumin Nanomicelles Paves a New Path for Antiobesity Technology"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6881-1577","authenticated-orcid":false,"given":"Cheng","family":"Bao","sequence":"first","affiliation":[{"name":"School of Life Sciences Ludong University  Yantai China"},{"name":"School of Transportation Ludong University  Yantai 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