{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T12:11:41Z","timestamp":1790424701339,"version":"4.1.0"},"reference-count":75,"publisher":"Wiley","issue":"32","license":[{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82301581"],"award-info":[{"award-number":["82301581"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Brachial plexus root avulsion (BPRA) results in extensive motor neurons (MNs) loss, muscle atrophy, and irreversible motor dysfunction. Current surgical strategies with reimplantation fail to promote the motor recovery often leading to poor clinical outcomes, because of the too slow re\u2010growth of the axons of MNs to re\u2010innervate the target muscles before atrophy happens. To reconstruct the neuroprotective microenvironment to reduce the MNs death following BPRA, we developed an injectable dual\u2010network HG\u03b1 composite hydrogel encapsulating a 6\u2032\u2010sialyllactose (6\u2032\u2010SL) mimetic peptide. The HG\u03b1 hydrogel was formed via Zn\n                    <jats:sup>2+<\/jats:sup>\n                    \u2010induced self\u2010assembly of glycyrrhizic acid (GA) to establish a primary physical network, combined with photocrosslinking of methacryloyl hyaluronic acid (HAMA) and 6\u2032\u2010SL mimetic peptide to form a secondary covalent network. In vitro studies demonstrated that HG\u03b1 exhibits favorable injectability and tissue adhesiveness. HG\u03b1 showed potent antioxidant capacity. In a rat BPRA model, at week 8, 50% of rats in the HG\u03b1\u2010treated group achieved a Terzis Grooming Test score of 5, HG\u03b1 hydrogel significantly improved in forelimb motor function, modulated the local inflammatory microenvironment to preserve the spinal MNs, promoted remyelination of musculocutaneous nerve, attenuated muscle atrophy, offering a promising strategy to restore motor function.\n                  <\/jats:p>","DOI":"10.1002\/adhm.71497","type":"journal-article","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T05:26:38Z","timestamp":1785389198000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Hyaluronic Acid\u2010Based Injectable Dual\u2010Network Hydrogel for 6\u2032\u2010Sialyllactose Mimetic Peptide Delivery and Microenvironment Reconstruction in Brachial Plexus Root Avulsion"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1559-6831","authenticated-orcid":false,"given":"Fubing","family":"Xiao","sequence":"first","affiliation":[{"name":"Hunan Key Laboratory of Typical Environmental Pollution and Health Hazards School of Public Health Hengyang Medical School University of South China  Hengyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Ding","sequence":"additional","affiliation":[{"name":"Hunan Key Laboratory of Typical Environmental Pollution and Health Hazards School of Public Health Hengyang Medical School University of South China  Hengyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong","family":"Ning","sequence":"additional","affiliation":[{"name":"Hunan Key Laboratory of Typical Environmental Pollution and Health Hazards School of Public Health Hengyang Medical School University of South China  Hengyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Neurology Multi\u2010Omics Research Center for Brain Disorders The First Affiliated Hospital Hengyang Medical School University of South China  Hengyang Hunan China"},{"name":"Clinical Research Center for Immune\u2010Related Encephalopathy of Hunan Province (The First Affiliated Hospital) Hengyang Medical School University of South China  Hengyang Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology Multi\u2010Omics Research Center for Brain Disorders The First Affiliated Hospital Hengyang Medical School University of South China  Hengyang Hunan China"},{"name":"Clinical Research Center for Immune\u2010Related Encephalopathy of Hunan Province (The First Affiliated Hospital) Hengyang Medical School University of South China  Hengyang Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5137-9549","authenticated-orcid":false,"given":"Zijian","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Neurology Multi\u2010Omics Research Center for Brain Disorders The First Affiliated Hospital Hengyang Medical School University of South China  Hengyang Hunan China"},{"name":"Clinical Research Center for Immune\u2010Related Encephalopathy of Hunan Province (The First Affiliated Hospital) Hengyang Medical School University of South China  Hengyang Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heng","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Neurology Multi\u2010Omics Research Center for Brain Disorders The First Affiliated Hospital Hengyang Medical School University of South China  Hengyang Hunan China"},{"name":"Clinical Research Center for Immune\u2010Related Encephalopathy of Hunan Province (The First Affiliated Hospital) Hengyang Medical School University of South China  Hengyang Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7711-9171","authenticated-orcid":false,"given":"Shuangxi","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology Multi\u2010Omics Research Center for Brain Disorders The First Affiliated Hospital Hengyang Medical School University of South China  Hengyang Hunan China"},{"name":"Clinical Research Center for Immune\u2010Related Encephalopathy of Hunan Province (The First Affiliated Hospital) Hengyang Medical School University of South China  Hengyang Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,29]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.11622\/smedj.2016166"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.2106\/jbjs.I.01602"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00590\u2010018\u20102345\u20101"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673\u20105374.141809"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.12269"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00234\u2010017\u20101796\u20100"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10143\u2010019\u201001100\u20109"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncpneuro0262"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12031\u2010015\u20100543\u20104"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12031\u2010021\u201001916\u20105"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2016.05.010"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.S0022\u20100302(03)73583\u20108"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.01.024"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01601"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673\u20105374.270313"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202003759"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202406376"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.129372"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2025.139872"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951\u2010026\u201004730\u20106"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matdes.2026.116123"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/term.1902"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201500762"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201303233"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10570\u2010024\u201005972\u2010z"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2023.100668"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202406950"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41536\u2010021\u201000174\u20108"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.9b00114"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064\u2010020\u201003120\u20100"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1080\/21691401.2020.1770265"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/exp.20230138"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/exp.20240133"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1039\/c1cs15203c"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2023.120934"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202306554"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6699560"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202304300"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2019.01.047"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.3c09615"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202306203"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2024.122780"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202200521"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2020.11.020"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2025.123144"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2026.138633"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.113686"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/ame2.70114"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mex.2019.10.012"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967\u2010023\u201004399\u20107"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10071614"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.70728"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.4c00717"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1093\/rb\/rbad023"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtcomm.2022.104660"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2022.12.009"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202201059"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/cssc.202400769"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1076\/1381\u20103455(200007)108:3;1\u2010z;ft293"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.0c01177"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1039\/d4bm01221f"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1002\/exp.20230066"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2025.148849"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.3c13551"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2025.114797"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2009.07.021"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jot.2025.02.007"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1007\/bf03182718"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097\u20104547(19990301)55:5<542::AID\u2010JNR2>3.0.CO;2\u20107"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2006.23.604"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974\u2010022\u201002632\u20106"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974\u2010020\u201001936\u20109"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxins13110827"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201053276\u20104"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23147489"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.71497","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adhm.71497","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.71497","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T04:52:29Z","timestamp":1787719949000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.71497"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,29]]},"references-count":75,"journal-issue":{"issue":"32","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1002\/adhm.71497"],"URL":"https:\/\/doi.org\/10.1002\/adhm.71497","archive":["Portico"],"relation":{},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,29]]},"assertion":[{"value":"2026-01-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71497"}}