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Precise control of pathogen colonization, effective modulation of local immune microenvironment, and activation of osteogenesis are spatiotemporal phases that pose significant clinical challenges. Here, we construct a multifunctional platform of copper\u2010zinc bimetallic metal\u2013organic nanosheets encapsulated in a polyvinylpyrrolidone\u2010polyvinyl alcohol hydrogel (CuZn\u2010MON@gel). Upon ultrasound irradiation, CuZn\u2010MON produces singlet oxygen, achieving antibacterial efficiencies of 99.93% against\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    and 99.78% against\n                    <jats:italic>Porphyromonas gingivalis<\/jats:italic>\n                    . In the absence of ultrasound, the nanozyme switches to SOD\u2010 and CAT\u2010like activities, scavenging excess reactive oxygen species and downregulating pro\u2010inflammatory pathways, including chemokine and NF\u2010\u03baB signaling pathway. Simultaneously, controlled release of osteogenic Cu\n                    <jats:sup>2+<\/jats:sup>\n                    and Zn\n                    <jats:sup>2+<\/jats:sup>\n                    ions activates AMPK and PI3K\/Akt pathways, enhancing the expression of osteogenic markers Runx2, ALP, OCN, and OPN. This system promotes osteogenic differentiation and accelerates bone regeneration in an infected rat model, achieving robust repair of jawbone defects. By dynamically balancing bactericidal ROS generation and antioxidant protection, CuZn\u2010MON@gel offers a spatiotemporal therapeutic strategy for reconstructing infectious bone defects.\n                  <\/jats:p>","DOI":"10.1002\/adhm.71499","type":"journal-article","created":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T04:22:24Z","timestamp":1785730944000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Spatiotemporal Sonodynamic\u2010Nanozymic Therapy for Infected Jawbone Defects"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-5210-7216","authenticated-orcid":false,"given":"Xin","family":"Liu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oral &amp; Maxillofacial Reconstruction and Regeneration Key Laboratory of Oral Biomedicine Ministry of Education Hubei Key Laboratory of Stomatology School &amp; Hospital of Stomatology Wuhan University  Wuhan P.R. 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