{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T05:20:57Z","timestamp":1787721657297,"version":"build-2784847793"},"reference-count":40,"publisher":"Wiley","issue":"32","license":[{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Second near\u2010infrared (NIR\u2010II, 1000\u20131700\u00a0nm) fluorescence imaging (FLI)\u2010guided photothermal therapy is a promising non\u2010invasive strategy for tumor theranostics. However, existing photothermal agents struggle to balance high photothermal conversion efficiency (PCE) with strong fluorescence quantum yield (QY). Herein, an alkoxyl side chain engineering strategy was proposed to construct a series of donor\u2010\u03c0 bridge\u2010acceptor\u2010\u03c0 bridge\u2010donor (D\u2010\u03c0\u2010A\u2010\u03c0\u2010D) structured organic photothermal agents (\n                    <jats:bold>TTQ1<\/jats:bold>\n                    \u2010\n                    <jats:bold>TTQ6<\/jats:bold>\n                    ) enabling simultaneous NIR\u2010II FLI\u2010guided photothermal therapy. By introducing different alkoxyl side chains on triphenylamine donor or thiophene \u03c0\u2010bridge, the photophysical properties including aggregation\u2010induced emission (AIE) property, QY and PCE were regulated.\n                    <jats:bold>TTQ2 NPs<\/jats:bold>\n                    and\n                    <jats:bold>TTQ6 NPs<\/jats:bold>\n                    featured superior resolution and low background in in vivo NIR\u2010II fluorescence imaging of the mouse blood vessels with high signal\u2010to\u2010noise ratio. Four alkoxyl chains attached to the donor moiety enhanced the intramolecular donor\u2010acceptor interaction and effectively suppressed aggregation\u2010caused quenching (ACQ), enabling\n                    <jats:bold>TTQ6 NPs<\/jats:bold>\n                    to exhibit desirable NIR\u2010II fluorescence and a high PCE of 46.5%. Encouragingly,\n                    <jats:bold>TTQ6 NPs<\/jats:bold>\n                    could effectively ablate both subcutaneous and orthotopic breast tumors and stimulate adaptive immune responses, which collectively reduced the risk of tumor recurrence. This study illustrates the potential of alkoxyl side chain engineering strategy in developing advanced photothermal agents for NIR\u2010II FLI\u2010guided theranostics.\n                  <\/jats:p>","DOI":"10.1002\/adhm.71500","type":"journal-article","created":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T05:01:54Z","timestamp":1785301314000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Tailoring NIR\u2010II Fluorescence and Photothermal Properties via Side\u2010Chain Engineering for Vascular Imaging and Image\u2010Guided Tumor Therapy"],"prefix":"10.1002","volume":"15","author":[{"given":"Yun\u2010Yun","family":"Quan","sequence":"first","affiliation":[{"name":"State Key Laboratory of Macromolecular Drugs and Large\u2010scale Manufacturing School of Pharmaceutical Sciences Wenzhou Medical University  Wenzhou 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