{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T05:20:31Z","timestamp":1787721631298,"version":"build-2784847793"},"reference-count":48,"publisher":"Wiley","issue":"32","license":[{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Seborrheic dermatitis (SD) is a chronic relapsing inflammatory dermatosis closely associated with\n                    <jats:italic>Malassezia furfur<\/jats:italic>\n                    overgrowth. Given the growing interest in metal\u2010based antimicrobials, copper compounds were investigated here as potential anti\u2010Malassezia agents for SD treatment. CuSO\n                    <jats:sub>4<\/jats:sub>\n                    showed the strongest antifungal activity against\n                    <jats:italic>M. furfur<\/jats:italic>\n                    at 1\u00a0mM and rapidly reduced fungal viability. Mechanistic analyses revealed intracellular copper accumulation, elevated Fe\n                    <jats:sup>2+<\/jats:sup>\n                    levels, increased reactive oxygen species generation, and enhanced lipid peroxidation, collectively suggesting an oxidative damage pattern with ferroptosis\u2010like features. Based on its potent anti\u2010Malassezia activity, a CuSO\n                    <jats:sub>4<\/jats:sub>\n                    \u2010loaded xanthan gum\/hyaluronic acid hydrogel (HG\u2010Cu) was further developed for integrated local treatment of seborrheic dermatitis. HG\u2010Cu exhibited viscous\u2010flow behavior, high structural stability, and favorable biocompatibility. In a guinea pig model of\n                    <jats:italic>M. furfur<\/jats:italic>\n                    \u2010induced seborrheic dermatitis, HG\u2010Cu effectively suppressed fungal proliferation in lesions through sustained copper release. Histopathological analysis showed that HG\u2010Cu markedly ameliorated skin lesions, reduced inflammatory infiltration, and promoted matrix reconstruction and skin repair by upregulating type III collagen (COL III) at the early stage and enhancing type I collagen (COL I) deposition at the later stage. Taken together, HG\u2010Cu offers a promising localized therapeutic approach for seborrheic dermatitis by integrating sustained antifungal activity, inflammation control, and skin barrier restoration.\n                  <\/jats:p>","DOI":"10.1002\/adhm.71501","type":"journal-article","created":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T04:51:03Z","timestamp":1785300663000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Therapeutic Copper Hydrogel for Seborrheic Dermatitis: From Fungal Eradication to Skin Lesion Repair"],"prefix":"10.1002","volume":"15","author":[{"given":"Lili","family":"Zhao","sequence":"first","affiliation":[{"name":"School of Food Science and Engineering Shaanxi University of Science and Technology  Xi'an 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