{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T08:16:13Z","timestamp":1788509773311,"version":"build-2803163510"},"reference-count":68,"publisher":"Wiley","issue":"33","license":[{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U22A20383"],"award-info":[{"award-number":["U22A20383"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["226\u20102025\u201000135"],"award-info":[{"award-number":["226\u20102025\u201000135"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Blood\u2013brain barrier (BBB) disruption is found in many acute and chronic inflammatory encephalopathies. Timely restoration of BBB integrity is essential for controlling disease progression, especially in ischemic stroke. While various brain\u2010targeting strategies have been developed, achieving precise BBB\u2010targeting and sustained retention at the BBB to enable faster and more effective repair remains a significant challenge. In this study, a biomimetic strategy is developed to enhance inflamed BBB\u2010targeting gene delivery using cationic hybrid nanovesicles derived from mesenchymal stem cell (MSC) membranes, named P(ML). The combined contributions of the positive surface charge and the biological targeting capability inherent to MSC membranes enable the precise inflamed BBB\u2010targeting of P(ML). In vitro and in vivo studies demonstrated that P(ML) efficiently accumulated in ischemic brain regions, and exhibited precise retention at\u00a0inflamed BBB, rather than a diffuse distribution within the whole brain. Additionally, P(ML) showed efficient nucleic acid delivery capability. When loaded with siRNA targeting p66\n                    <jats:sup>Shc<\/jats:sup>\n                    , a protein involved in endothelial dysfunction, P(ML) exhibited significant protective effects on the injured BBB in animal models. This biomimetic P(ML) nanocarrier platform represents a promising strategy for inflamed BBB\u2010targeting gene delivery, offering potential therapeutic applications for ischemic stroke and other BBB\u2010related disorders.\n                  <\/jats:p>","DOI":"10.1002\/adhm.71503","type":"journal-article","created":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T04:32:48Z","timestamp":1785472368000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Targeted Retention of Cationic Liposomes at the Inflamed Blood\u2013Brain Barrier by Incorporating Mesenchymal Stem Cell Membrane"],"prefix":"10.1002","volume":"15","author":[{"given":"Juanjuan","family":"Zheng","sequence":"first","affiliation":[{"name":"State Key Laboratory of Advanced Drug Delivery and Release Systems School of Pharmacy Zhejiang University  Hangzhou Zhejiang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Advanced Drug Delivery and Release Systems School of Pharmacy Zhejiang University  Hangzhou Zhejiang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaosheng","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Advanced Drug Delivery and Release Systems School of Pharmacy Zhejiang University  Hangzhou Zhejiang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuankai","family":"Sun","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Advanced Drug Delivery and Release Systems School of Pharmacy Zhejiang University  Hangzhou Zhejiang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zefeng","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Advanced Drug Delivery and Release Systems School of Pharmacy Zhejiang University  Hangzhou Zhejiang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xunqi","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Advanced Drug Delivery and Release Systems School of Pharmacy Zhejiang University  Hangzhou Zhejiang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiwei","family":"Du","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Advanced Drug Delivery and Release Systems School of Pharmacy Zhejiang University  Hangzhou Zhejiang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahe","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province, Affiliated Hangzhou First People's Hospital, School of Medicine Westlake University  Hangzhou Zhejiang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Pei","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Advanced Drug Delivery and Release Systems School of Pharmacy Zhejiang University  Hangzhou Zhejiang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Qiu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Advanced Drug Delivery and Release Systems School of Pharmacy Zhejiang University  Hangzhou Zhejiang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-5444-4078","authenticated-orcid":false,"given":"Yu","family":"Zhao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Advanced Drug Delivery and Release Systems School of Pharmacy Zhejiang University  Hangzhou Zhejiang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinchi","family":"Jiang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Advanced Drug Delivery and Release Systems School of Pharmacy Zhejiang University  Hangzhou Zhejiang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1052-7060","authenticated-orcid":false,"given":"Jianqing","family":"Gao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Advanced Drug Delivery and Release Systems School of Pharmacy Zhejiang University  Hangzhou Zhejiang People's Republic of China"},{"name":"Innovation Center of Yangtze River Delta Zhejiang University  Jiaxing Zhejiang People's Republic of China"},{"name":"Department of Pharmacy The Second Affiliated Hospital of Zhejiang University School of Medicine  Hangzhou Zhejiang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,30]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010cellbio\u2010100617\u2010062608"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010024\u201007314\u20102"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010023\u201001688\u2010x"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00050.2017"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2016.03.010"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awv203"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp\u20102017\u2010ABN.103"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms11934"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2008.01.003"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202410404"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330\u2010017\u20105025\u20103"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms10523"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox13121462"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2024.116186"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.122.039337"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abn7921"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3407"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41583\u2010024\u201000892\u20100"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.120.031410"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2017.62"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.119.315886"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz712"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-9798-5_14"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41570\u2010025\u201000770\u2010y"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2016.06.001"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.aaa2581"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.637884"},{"key":"e_1_2_10_29_1","first-page":"5864","article-title":"A Pluripotential Neutrophil\u2010Mimic Nanovehicle Modulates Immune Microenvironment With Targeted Drug Delivery for Augmented Antitumor Chemotherapy","volume":"18","author":"Wu J.","year":"2024","journal-title":"ACS Nano"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571\u2010022\u201000699\u2010x"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2025.114321"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202006169"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2023.101800"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010024\u201001936\u20108"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2022.114619"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2024.06.017"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2023.102615"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2013.09.013"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241713542"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2022.09.012"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916\u2010024\u201003768\u20103"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010025\u201058254\u2010y"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2024.122616"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00050.2022"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202300319"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41578\u2010023\u201000552\u20102"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2021.05.019"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201706759"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/nnano.2012.207"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn501668a"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010024\u201002035\u20104"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/EXP.20230147"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.275.5301.810"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2307800120"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010024\u201001755\u2010x"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv140"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2014.03.017"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2023.10.012"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/VIW.20240043"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010025\u201061688\u2010z"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201053914\u2010x"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010022\u201001064\u20101"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0324\u201018.2018"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010025\u201056720\u20101"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201052346\u2010x"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010025\u201062613\u20100"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201807591"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.32.4.1005"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010026\u201070340\u20103"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.71503","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adhm.71503","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.71503","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T07:49:32Z","timestamp":1788508172000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.71503"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,30]]},"references-count":68,"journal-issue":{"issue":"33","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/adhm.71503"],"URL":"https:\/\/doi.org\/10.1002\/adhm.71503","archive":["Portico"],"relation":{},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,30]]},"assertion":[{"value":"2026-02-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71503"}}