{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T08:16:44Z","timestamp":1788509804040,"version":"build-2803163510"},"reference-count":44,"publisher":"Wiley","issue":"33","license":[{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52425312"],"award-info":[{"award-number":["52425312"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51973218"],"award-info":[{"award-number":["51973218"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The therapeutic efficacy of melanoma immunochemotherapy is severely limited by insufficient intratumoral drug retention, systemic toxicity, and immunosuppressive tumor microenvironment (TME). Thus, we developed a single\u2010dose injectable localized chemo\u2010immunotherapy platform that enables sustained tumor\u2010restricted delivery and synergistic immune remodeling. This hybrid system integrates doxorubicin\u2010loaded tumor\u2010derived exosome\u2010coated hollow mesoporous silica nanoparticles (DeH) with a mannose\u2010modified \u03b2\u2010cyclodextrin\u2010polyethyleneimine carrier co\u2010delivering dual Toll\u2010like receptor agonists (RC\u2010MCP) within a thermoresponsive polypeptide hydrogel (mPEG\u2010\n                    <jats:italic>b<\/jats:italic>\n                    \u2010PELG). The biomimetic exosome coating provides an exosome\u2010sheathed nanostructure and amplifies doxorubicin\u2010induced immunogenic cell death. Mannose\u2010mediated targeting facilitates preferential uptake by antigen\u2010presenting cells and enhances endosomal Toll\u2010like receptor signaling, leading to robust dendritic cell maturation. Following intratumoral injection, the hydrogel undergoes in situ sol\u2010gel transition to form a stable drug depot, enabling sustained and coordinated release while minimizing systemic exposure. As a result, a single intratumoral administration elicits potent antitumor immune responses, significantly suppresses tumor growth, alleviates TME immunosuppression, and exhibits favorable biocompatibility in murine melanoma model. Collectively, this work presents a rationally designed single\u2010dose localized chemo\u2010immunotherapy strategy for melanoma treatment.\n                  <\/jats:p>","DOI":"10.1002\/adhm.71506","type":"journal-article","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T08:57:31Z","timestamp":1785401851000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Injectable Thermoresponsive Hybrid Hydrogel for Localized Chemo\u2010Immunotherapy via Co\u2010Delivery of Doxorubicin\u2010Loaded Tumor\u2010Derived Exosomes and Immunoadjuvants"],"prefix":"10.1002","volume":"15","author":[{"given":"Yunan","family":"Yuan","sequence":"first","affiliation":[{"name":"State Key Laboratory of Polymer Science and Technology Changchun Institute of Applied Chemistry Chinese Academy of Sciences  Changchun China"},{"name":"School of Applied Chemistry and Engineering University of Science and Technology of China  Hefei 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