{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T15:27:55Z","timestamp":1790782075702,"version":"4.1.0"},"reference-count":47,"publisher":"Wiley","issue":"33","license":[{"start":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:00:00Z","timestamp":1785801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:00:00Z","timestamp":1785801600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The diabetic\u2010infected wound microenvironment, marked by elevated reactive oxygen species (ROS) levels, ongoing inflammation, and defective angiogenesis, interferes with the normal wound healing cascade and contributes to delayed and treatment\u2010resistant repair. However, most existing wound dressings lack the capability to dynamically adapt to these spatiotemporally evolving conditions. Herein, a smart and microenvironment\u2010programmable PVH\u2010ST hydrogel is developed to achieve phased and spatiotemporally coordinated regulation of diabetic\u2010infected wound healing. The hydrogel is engineered by integrating strontium (Sr)\u2010tannic acid (ST) nanoparticles into a polyvinyl alcohol (PVA) and hyaluronic acid (HA) matrix through a boric acid\u2010mediated multilevel dynamic crosslinking network, endowing the system with mechanical robustness suitable for daily motion. Upon wound occurrence, the PVH\u2010ST hydrogel rapidly induces hemostasis and establishes a bioactive provisional matrix. In response to the ROS\u2010enriched infected microenvironment, the dynamic borate bonds undergo on\u2010demand dissociation, triggering controlled release of ST nanoparticles. Released ST nanoparticles integrate antibacterial and antioxidant functions and reduce inflammatory burden via modulation of NF\u2010\u03baB signaling and skewing macrophages toward an M2 pro\u2010regenerative state. Concurrently, the sustained release of Sr\n                    <jats:sup>2+<\/jats:sup>\n                    ions activates VEGF\u2010associated angiogenic signaling and epithelialization pathways, thereby promoting vascularization and epithelial reconstruction for diabetic\u2010infected wounds.\n                  <\/jats:p>","DOI":"10.1002\/adhm.71516","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T04:36:41Z","timestamp":1785904601000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Programming the Diabetic\u2010Infected Wound Microenvironment With a Smart Hydrogel for Ordered Healing Cascade Restoration"],"prefix":"10.1002","volume":"15","author":[{"given":"Aihong","family":"Chen","sequence":"first","affiliation":[{"name":"School of Chemistry and Chemical Engineering Shanghai University of Engineering Science  Shanghai China"},{"name":"The Department of Emergency and 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