{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T18:13:58Z","timestamp":1790792038275,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"33","license":[{"start":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T00:00:00Z","timestamp":1785715200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T00:00:00Z","timestamp":1785715200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22407083"],"award-info":[{"award-number":["22407083"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Photodynamic therapy (PDT) is a promising minimally invasive antitumor approach, but its clinical efficacy is severely limited by the single Type\u2011II reaction of conventional photosensitizers (PSs), insufficient subcellular targeting and poor performance in hypoxic tumors. Herein, a lysosome\u2011targeted D\u2011\u2010\u03c0\u2010\u2011A near\u2011infrared PS\n                    <jats:bold>Lyso\u2011IsTp<\/jats:bold>\n                    was designed and synthesized, with isophorone as acceptor, methoxy\u2011modified triphenylamine as donor, benzene as \u03c0\u2011bridge and 4\u2011(2\u2011chloroethyl)morpholine as targeting moiety. It emitted fluorescence at 750\u00a0nm with good photostability and solvent\u2011dependent properties. Under 660\u00a0nm irradiation,\n                    <jats:bold>Lyso\u2011IsTp<\/jats:bold>\n                    simultaneously produced Type\u2011I (\u2022OH, O\n                    <jats:sub>2<\/jats:sub>\n                    <jats:sup>\u2212\u2022<\/jats:sup>\n                    ) and Type\u2010II (\n                    <jats:sup>1<\/jats:sup>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    ) ROS. Confocal imaging confirmed its excellent lysosome targeting in HeLa cells with a Pearson coefficient of 0.97. It showed negligible dark toxicity and remarkable phototoxicity, inducing apoptosis via ROS\u2011mediated lysosomal damage. In vivo studies on tumor\u2011bearing nude mice revealed that\n                    <jats:bold>Lyso\u2011IsTp<\/jats:bold>\n                    \u2011mediated PDT significantly inhibited tumor growth with obvious necrosis. Biosafety tests including body weight, H&amp;E staining, and blood analysis demonstrated no obvious systemic toxicity or organ damage. This work provides a high\u2011performance lysosome\u2011targeted NIR PS with dual ROS generation, offering a feasible strategy for hypoxia\u2011tolerant and organelle\u2011specific antitumor PDT.\n                  <\/jats:p>","DOI":"10.1002\/adhm.71517","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T05:01:44Z","timestamp":1785819704000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Lysosome\u2010Targeted D\u2013\u03c0\u2013A Near\u2010Infrared Photosensitizer With Dual Type\u2010I\/Type\u2010II ROS Generation for Hypoxia\u2010Resilient Photodynamic Tumor Therapy"],"prefix":"10.1002","volume":"15","author":[{"given":"Yongfei","family":"Huang","sequence":"first","affiliation":[{"name":"School of Chemistry and Chemical Engineering Shanxi Normal University  TaiYuan 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