{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T08:15:56Z","timestamp":1788509756901,"version":"build-2803163510"},"reference-count":177,"publisher":"Wiley","issue":"33","license":[{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC3701302"],"award-info":[{"award-number":["2022YFC3701302"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22276199"],"award-info":[{"award-number":["22276199"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Manganese\u2010ion\u2010based nanoparticles have emerged as highly versatile platforms that seamlessly integrate diagnostic and therapeutic functions, enabling precision cancer theranostics. In this review, we discuss manganese\u2010based nanomaterials through a design\u2010oriented framework that connects synthesis, structure, function, application, and limitation. Mainstream preparation strategies, including thermal decomposition, permanganate reduction, hydrothermal\/solvothermal synthesis, template\u2010assisted construction, coprecipitation, and mild biomimetic routes, are compared with respect to physicochemical control, Mn activation behavior, scalability, and biomedical suitability. The diagnostic applications of manganese\u2010based nanoplatforms are discussed, including activatable T\n                    <jats:sub>1<\/jats:sub>\n                    \u2010weighted magnetic resonance imaging (MRI) and multimodal imaging systems, as well as Mn\u2010activated DNAzyme platforms for gene regulation. We further review therapeutic modalities enabled by Mn\n                    <jats:sup>2<\/jats:sup>\n                    <jats:sup>+<\/jats:sup>\n                    , encompassing chemodynamic therapy (CDT), nanozyme\u2010mediated redox regulation within the tumor microenvironment, stimulus\u2010responsive drug and prodrug delivery, magnetic hyperthermia, and their synergistic combinations. Finally, we critically analyze key biosafety considerations along with current translational challenges and future perspectives for developing clinically viable, image\u2010guided combination cancer therapies based on manganese\u2010ion nanoplatforms.\n                  <\/jats:p>","DOI":"10.1002\/adhm.71519","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T10:37:38Z","timestamp":1785926258000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Manganese Ion\u2010Based NanoPlatforms for Tumor Theranostics"],"prefix":"10.1002","volume":"15","author":[{"given":"Xiangzhou","family":"Li","sequence":"first","affiliation":[{"name":"State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco\u2010Environmental Sciences Chinese Academy of Sciences  Beijing China"},{"name":"University of Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjing","family":"Xie","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco\u2010Environmental Sciences Chinese Academy of Sciences  Beijing China"},{"name":"University of Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Jin","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco\u2010Environmental Sciences Chinese Academy of Sciences  Beijing China"},{"name":"University of Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianrui","family":"Sun","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco\u2010Environmental Sciences Chinese Academy of Sciences  Beijing China"},{"name":"University of Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingxu","family":"Shang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco\u2010Environmental Sciences Chinese Academy of Sciences  Beijing China"},{"name":"University of Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaojia","family":"Deng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco\u2010Environmental Sciences Chinese Academy of Sciences  Beijing China"},{"name":"University of Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7079-0827","authenticated-orcid":false,"given":"Hanyong","family":"Peng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco\u2010Environmental Sciences Chinese Academy of Sciences  Beijing China"},{"name":"University of Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,5]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21871"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.70011"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41563\u2010021\u201001047\u20107"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.09.024"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics16070932"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20114"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1039\/c8cs00618k"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201805664"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.40805"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41565\u2010020\u201000817\u20109"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.7b00258"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202312169"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.2147\/ijn.S426311"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28217275"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2025.05.058"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2011.07.076"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.50028"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2025.07.010"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951\u2010024\u201002502\u20108"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2022.04.011"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2015.2297"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.2147\/ijn.S132270"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.14431"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1515\/nanoph\u20102022\u20100533"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.7150\/ntno.57657"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0239034"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/smtd.202400018"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.3c07306"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.5c01922"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2025.04.040"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1039\/c6tb00718j"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja993280v"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja0362656"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200352400"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmat1251"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1021\/cm052492q"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c09052"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201500908"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.200701231"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn405773r"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2017.00109"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja2100774"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.2147\/ijn.S128844"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202100518"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtchem.2026.103621"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2025.1582490"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja0177105"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrysgro.2006.06.046"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.200700698"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3nr05687b"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201706090"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2024.113834"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.34133\/bmr.0092"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cplett.2020.137283"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1039\/b402209b"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matlet.2010.03.067"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.3c01176"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/2302595"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201901124"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/nnano.2016.72"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201700373"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201702835"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201411417"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja5029364"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.inorgchem.4c05083"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2025.139121"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1039\/c8tb00135a"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202415656"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202503004"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.34133\/bmr.0158"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201800770"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2024.124824"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201712027"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1039\/c6nr07062k"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2017.08.028"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2015.11.036"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2021.102440"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1039\/d2ra03860a"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1088\/1361\u20106528\/abfc6f"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1021\/ar200124g"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.langmuir.2c03121"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2025.123359"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.3390\/nano11040876"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.22989"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2023.1249472"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943\u2010025\u201002242\u20109"},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfk062"},{"key":"e_1_2_9_89_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.13131669"},{"key":"e_1_2_9_90_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.rli.0000184756.66360.d3"},{"key":"e_1_2_9_91_1","doi-asserted-by":"publisher","DOI":"10.1080\/02841859709172403"},{"key":"e_1_2_9_92_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja1084095"},{"key":"e_1_2_9_93_1","doi-asserted-by":"publisher","DOI":"10.1021\/nl071099b"},{"key":"e_1_2_9_94_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmmi.265"},{"key":"e_1_2_9_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2015.11.010"},{"key":"e_1_2_9_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2016.05.054"},{"key":"e_1_2_9_97_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym14173540"},{"key":"e_1_2_9_98_1","doi-asserted-by":"publisher","DOI":"10.1039\/d4ra02340d"},{"key":"e_1_2_9_99_1","doi-asserted-by":"publisher","DOI":"10.1039\/d4sc00907j"},{"key":"e_1_2_9_100_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41377\u2010022\u201000794\u20109"},{"key":"e_1_2_9_101_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.77060"},{"key":"e_1_2_9_102_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202207486"},{"key":"e_1_2_9_103_1","doi-asserted-by":"publisher","DOI":"10.1039\/d5sc00568j"},{"key":"e_1_2_9_104_1","doi-asserted-by":"publisher","DOI":"10.2147\/ijn.S461701"},{"key":"e_1_2_9_105_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.0c09223"},{"key":"e_1_2_9_106_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010017\u201001050\u20100"},{"key":"e_1_2_9_107_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41422\u2010020\u201000395\u20104"},{"key":"e_1_2_9_108_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010nutr\u2010071714\u2010034419"},{"key":"e_1_2_9_109_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951\u2010021\u201000936\u2010y"},{"key":"e_1_2_9_110_1","doi-asserted-by":"publisher","DOI":"10.1039\/d4ra01655f"},{"key":"e_1_2_9_111_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202305979"},{"key":"e_1_2_9_112_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202503072"},{"key":"e_1_2_9_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2019.03.070"},{"key":"e_1_2_9_114_1","doi-asserted-by":"publisher","DOI":"10.1039\/c9tb02524c"},{"key":"e_1_2_9_115_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202416686"},{"key":"e_1_2_9_116_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsmaterialslett.3c01459"},{"key":"e_1_2_9_117_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.8b08101"},{"key":"e_1_2_9_118_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biochem.1c00091"},{"key":"e_1_2_9_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2020.119513"},{"key":"e_1_2_9_120_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.2c04022"},{"key":"e_1_2_9_121_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.1c01727"},{"key":"e_1_2_9_122_1","doi-asserted-by":"publisher","DOI":"10.1039\/d4sc01147c"},{"key":"e_1_2_9_123_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202113619"},{"key":"e_1_2_9_124_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.2c02788"},{"key":"e_1_2_9_125_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c02354"},{"key":"e_1_2_9_126_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c09581"},{"key":"e_1_2_9_127_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202318530"},{"key":"e_1_2_9_128_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41568\u2010022\u201000496\u20109"},{"key":"e_1_2_9_129_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsabm.0c00156"},{"key":"e_1_2_9_130_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046\u2010021\u201002000\u2010x"},{"key":"e_1_2_9_131_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1145551"},{"key":"e_1_2_9_132_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2021.02.004"},{"key":"e_1_2_9_133_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202204951"},{"key":"e_1_2_9_134_1","doi-asserted-by":"publisher","DOI":"10.1039\/d5tb01925g"},{"key":"e_1_2_9_135_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23094936"},{"key":"e_1_2_9_136_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201600676"},{"key":"e_1_2_9_137_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41418\u2010017\u20100012\u20104"},{"key":"e_1_2_9_138_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951\u2010025\u201003694\u20103"},{"key":"e_1_2_9_139_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.03.042"},{"key":"e_1_2_9_140_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature15514"},{"key":"e_1_2_9_141_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010immunol\u2010032712\u2010100008"},{"key":"e_1_2_9_142_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.19323"},{"key":"e_1_2_9_143_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40580\u2010024\u201000456\u2010z"},{"key":"e_1_2_9_144_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951\u2010024\u201002629\u20108"},{"key":"e_1_2_9_145_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2021.10.032"},{"key":"e_1_2_9_146_1","doi-asserted-by":"publisher","DOI":"10.2147\/ijn.S365570"},{"key":"e_1_2_9_147_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1133011"},{"key":"e_1_2_9_148_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951\u2010023\u201001819\u20100"},{"key":"e_1_2_9_149_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010025\u201010182\u2010z"},{"key":"e_1_2_9_150_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2021.07.092"},{"key":"e_1_2_9_151_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2022.116870"},{"key":"e_1_2_9_152_1","doi-asserted-by":"publisher","DOI":"10.1039\/d4ay01283f"},{"key":"e_1_2_9_153_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2024.117724"},{"key":"e_1_2_9_154_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.3c10733"},{"key":"e_1_2_9_155_1","doi-asserted-by":"publisher","DOI":"10.1039\/c9nr03131f"},{"key":"e_1_2_9_156_1","doi-asserted-by":"publisher","DOI":"10.1039\/d5nh00254k"},{"key":"e_1_2_9_157_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.9b08318"},{"key":"e_1_2_9_158_1","doi-asserted-by":"publisher","DOI":"10.3390\/nano11051231"},{"key":"e_1_2_9_159_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.5c00983"},{"key":"e_1_2_9_160_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2020.120079"},{"key":"e_1_2_9_161_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15030818"},{"key":"e_1_2_9_162_1","doi-asserted-by":"publisher","DOI":"10.3390\/nano10112297"},{"key":"e_1_2_9_163_1","doi-asserted-by":"publisher","DOI":"10.1136\/jitc\u20102019\u2010000337"},{"key":"e_1_2_9_164_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.9b08550"},{"key":"e_1_2_9_165_1","doi-asserted-by":"publisher","DOI":"10.1039\/d1cc01375k"},{"key":"e_1_2_9_166_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159\u20108290.CD\u201021\u20101059"},{"key":"e_1_2_9_167_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41523\u2010022\u201000468\u20100"},{"key":"e_1_2_9_168_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(21)00312\u20103"},{"key":"e_1_2_9_169_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(19)32319\u20100"},{"key":"e_1_2_9_170_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(22)01200\u20104"},{"key":"e_1_2_9_171_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci129710"},{"key":"e_1_2_9_172_1","doi-asserted-by":"publisher","DOI":"10.1177\/07482337241242508"},{"key":"e_1_2_9_173_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010025\u201006345\u20107"},{"key":"e_1_2_9_174_1","doi-asserted-by":"publisher","DOI":"10.3390\/jpm11080771"},{"key":"e_1_2_9_175_1","doi-asserted-by":"publisher","DOI":"10.3390\/clinpract15080137"},{"key":"e_1_2_9_176_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010018\u201003705\u2010y"},{"key":"e_1_2_9_177_1","doi-asserted-by":"publisher","DOI":"10.3390\/jpm11030229"},{"key":"e_1_2_9_178_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.31233"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.71519","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adhm.71519","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.71519","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T07:49:55Z","timestamp":1788508195000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.71519"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,5]]},"references-count":177,"journal-issue":{"issue":"33","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/adhm.71519"],"URL":"https:\/\/doi.org\/10.1002\/adhm.71519","archive":["Portico"],"relation":{},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,5]]},"assertion":[{"value":"2026-02-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71519"}}