{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T08:15:56Z","timestamp":1788509756873,"version":"build-2803163510"},"reference-count":395,"publisher":"Wiley","issue":"33","license":[{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100018617","name":"Liaoning Revitalization Talents Program","doi-asserted-by":"publisher","award":["XLYC2403107"],"award-info":[{"award-number":["XLYC2403107"]}],"id":[{"id":"10.13039\/501100018617","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Osteoarthritis (OA) represents a self\u2010sustaining degenerative process characterized by maladaptive interactions among the cartilage, bone, and synovium triads, with current palliative treatments falling short of addressing its pathophysiological intricacies. Recently, injectable hydrogels specifically designed to tackle the distinct challenges of OA have emerged as a potential solution, offering significant advantages over traditional therapies through innovative integration. This review offers a comprehensive examination of the latest advancements in injectable hydrogel\u2010based therapies for managing OA. First, we dissect the molecular and cellular mechanisms that drive OA progression, placing specific attention on microenvironmental dysregulation. Next, we analyze various hydrogel design strategies, such as matrix composition, crosslinking methods, and stimulus\u2010responsive release, that influence mechanical strength and therapeutic precision. Additionally, we discuss the multifunctional potential of engineered hydrogels, particularly their exceptional ability to support targeted drug delivery. Finally, this review emphasizes the novel potential of these engineered systems to address the unique challenges related to OA management while overcoming the limitations of existing therapies, thereby positioning them as transformative tools for future clinical applications.<\/jats:p>","DOI":"10.1002\/adhm.71520","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T04:00:14Z","timestamp":1785988814000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Engineered Injectable Hydrogel Platform for Tailoring the Osteoarthritis Microenvironment"],"prefix":"10.1002","volume":"15","author":[{"given":"Jiaping","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Pharmaceutics, Wuya College of Innovation Shenyang Pharmaceutical University  Shenyang P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianbin","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, Wuya College of Innovation Shenyang Pharmaceutical University  Shenyang P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyang","family":"Luo","sequence":"additional","affiliation":[{"name":"College of Chemistry Jilin University  Jilin P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhonggui","family":"He","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, Wuya College of Innovation Shenyang Pharmaceutical University  Shenyang P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8230-4021","authenticated-orcid":false,"given":"Xiao","family":"Kuang","sequence":"additional","affiliation":[{"name":"Department of Center Laboratory, Punan Branch of Renji Hospital, School of Medicine Shanghai Jiao Tong University  Shanghai P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5844-8957","authenticated-orcid":false,"given":"Shenwu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, Wuya College of Innovation Shenyang Pharmaceutical University  Shenyang P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,5]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(83)90003\u2010x"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2016.72"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2025.1696929"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2025.1636976"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0049\u20100172(76)90015\u20109"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2016.65"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1903768"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/0036933015619588"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(07)61879\u20100"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2016.01.135"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/jfmk6010015"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/life12070982"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41563\u2010023\u201001472\u2010w"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.2c00179"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/rb\/rbag009"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cis.2023.103030"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2018.03.007"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2025.1644222"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.3c01160"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2026.1751293"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1940.20.2.272"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0928\u20104680(00)00044\u20104"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2011.06.037"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41584\u2010021\u201000747\u20103"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.22171"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports\u20102017\u2010098661"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1177\/1941738109350438"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/0049\u20100172(91)90035\u2010x"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030\u20104220(85)90367\u20106"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.34451"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/561459"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/8293921"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2019.116786"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.3390\/biology9040065"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.20170"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2018.10.002"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jot.2021.07.001"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2021.105497"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2025.06.003"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.3109\/03008207.2014.925885"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2024.10.027"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2021.110634"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.659654"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.1010818"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2007.06.009"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17091496"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.1302\/2058\u20105241.4.180102"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar4405"},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.1309\/lww3\u20105xk0\u2010fkg9\u2010hdrk"},{"key":"e_1_2_13_51_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.54.5.398"},{"key":"e_1_2_13_52_1","doi-asserted-by":"publisher","DOI":"10.3233\/bir\u20101987\u201024404"},{"key":"e_1_2_13_53_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.54.5.417"},{"key":"e_1_2_13_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2016.05.009"},{"key":"e_1_2_13_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41584\u2010022\u201000749\u20109"},{"key":"e_1_2_13_56_1","doi-asserted-by":"publisher","DOI":"10.1093\/jhps\/hnz073"},{"key":"e_1_2_13_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2019.11.009"},{"key":"e_1_2_13_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bj.2016.06.003"},{"key":"e_1_2_13_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010020\u201063493\u20108"},{"key":"e_1_2_13_60_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports\u20102018\u2010099257"},{"key":"e_1_2_13_61_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/key274"},{"key":"e_1_2_13_62_1","doi-asserted-by":"publisher","DOI":"10.3233\/bmr\u2010191504"},{"key":"e_1_2_13_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2009.08.013"},{"key":"e_1_2_13_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2011.09.001"},{"key":"e_1_2_13_65_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis\u20102012\u2010202745"},{"key":"e_1_2_13_66_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40122\u2010021\u201000260\u20101"},{"key":"e_1_2_13_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2020.09.001"},{"key":"e_1_2_13_68_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40266\u2010019\u201000666\u20109"},{"key":"e_1_2_13_69_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12306\u2010016\u20100428\u2010x"},{"key":"e_1_2_13_70_1","doi-asserted-by":"publisher","DOI":"10.1002\/jps.21346"},{"key":"e_1_2_13_71_1","doi-asserted-by":"publisher","DOI":"10.3390\/jfmk6010015"},{"key":"e_1_2_13_72_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41584\u2010018\u20100123\u20104"},{"key":"e_1_2_13_73_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00264\u2010022\u201005611\u2010x"},{"key":"e_1_2_13_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cis.2020.102273"},{"key":"e_1_2_13_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otsr.2019.09.002"},{"key":"e_1_2_13_76_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41536\u2010019\u20100069\u20104"},{"key":"e_1_2_13_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2019.03.011"},{"key":"e_1_2_13_78_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11926\u2010020\u20100884\u2010z"},{"key":"e_1_2_13_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2022.01.003"},{"key":"e_1_2_13_80_1","doi-asserted-by":"publisher","DOI":"10.1177\/1947603518783449"},{"key":"e_1_2_13_81_1","doi-asserted-by":"publisher","DOI":"10.1039\/b713009k"},{"key":"e_1_2_13_82_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines12040923"},{"key":"e_1_2_13_83_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202009432"},{"key":"e_1_2_13_84_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40779\u2010022\u201000439\u20103"},{"key":"e_1_2_13_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2019.03.011"},{"key":"e_1_2_13_86_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202101479"},{"key":"e_1_2_13_87_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.6b01619"},{"key":"e_1_2_13_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2020.116364"},{"key":"e_1_2_13_89_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202204283"},{"key":"e_1_2_13_90_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11926\u2010003\u20100077\u20106"},{"key":"e_1_2_13_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2025.142677"},{"key":"e_1_2_13_92_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12040824"},{"key":"e_1_2_13_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matdes.2024.112966"},{"key":"e_1_2_13_94_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.4c00372"},{"key":"e_1_2_13_95_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010025\u201022080\u20105"},{"key":"e_1_2_13_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2025.142050"},{"key":"e_1_2_13_97_1","doi-asserted-by":"publisher","DOI":"10.1002\/btm2.10475"},{"key":"e_1_2_13_98_1","doi-asserted-by":"publisher","DOI":"10.1039\/d3bm01008b"},{"key":"e_1_2_13_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2023.100813"},{"key":"e_1_2_13_100_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202305023"},{"key":"e_1_2_13_101_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0342242"},{"key":"e_1_2_13_102_1","doi-asserted-by":"publisher","DOI":"10.1039\/d4tb00624k"},{"key":"e_1_2_13_103_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.4c00200"},{"key":"e_1_2_13_104_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13018\u2010024\u201005411\u20106"},{"key":"e_1_2_13_105_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11061210"},{"key":"e_1_2_13_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2021.118352"},{"key":"e_1_2_13_107_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsabm.5c00576"},{"key":"e_1_2_13_108_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010025\u201090389\u20102"},{"key":"e_1_2_13_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmst.2022.09.061"},{"key":"e_1_2_13_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2023.05.003"},{"key":"e_1_2_13_111_1","doi-asserted-by":"publisher","DOI":"10.36899\/japs.2026.1.0010"},{"key":"e_1_2_13_112_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaz3041"},{"key":"e_1_2_13_113_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym14050986"},{"key":"e_1_2_13_114_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201801651"},{"key":"e_1_2_13_115_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201041594\u2010y"},{"key":"e_1_2_13_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2024.07.018"},{"key":"e_1_2_13_117_1","doi-asserted-by":"publisher","DOI":"10.1186\/s42825\u2010025\u201000221\u2010w"},{"key":"e_1_2_13_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioadv.2022.212804"},{"key":"e_1_2_13_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2023.102080"},{"key":"e_1_2_13_120_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202302833"},{"key":"e_1_2_13_121_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010food\u2010031414\u2010111800"},{"key":"e_1_2_13_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibtech.2019.12.005"},{"key":"e_1_2_13_123_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.4c00743"},{"key":"e_1_2_13_124_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202407522"},{"key":"e_1_2_13_125_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.24688"},{"key":"e_1_2_13_126_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201038597\u20100"},{"key":"e_1_2_13_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2021.03.022"},{"key":"e_1_2_13_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcjp.2024.100174"},{"key":"e_1_2_13_129_1","doi-asserted-by":"publisher","DOI":"10.3390\/coatings14091083"},{"key":"e_1_2_13_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.procbio.2023.03.009"},{"key":"e_1_2_13_131_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202405049"},{"key":"e_1_2_13_132_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e14349"},{"key":"e_1_2_13_133_1","doi-asserted-by":"publisher","DOI":"10.3390\/jfb14010039"},{"key":"e_1_2_13_134_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2021.01.157"},{"key":"e_1_2_13_135_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2025.123266"},{"key":"e_1_2_13_136_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202105063"},{"key":"e_1_2_13_137_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2023.114728"},{"key":"e_1_2_13_138_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2021.03.067"},{"key":"e_1_2_13_139_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2023.114857"},{"key":"e_1_2_13_140_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.adh9751"},{"key":"e_1_2_13_141_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph17040471"},{"key":"e_1_2_13_142_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.3c18464"},{"key":"e_1_2_13_143_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2023.100884"},{"key":"e_1_2_13_144_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2023.10.020"},{"key":"e_1_2_13_145_1","doi-asserted-by":"publisher","DOI":"10.3390\/gels10080508"},{"key":"e_1_2_13_146_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.136312"},{"key":"e_1_2_13_147_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2024.122706"},{"key":"e_1_2_13_148_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.2c00445"},{"key":"e_1_2_13_149_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.2c01144"},{"key":"e_1_2_13_150_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2021.04.003"},{"key":"e_1_2_13_151_1","doi-asserted-by":"publisher","DOI":"10.3390\/gels8060382"},{"key":"e_1_2_13_152_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.4c00817"},{"key":"e_1_2_13_153_1","doi-asserted-by":"publisher","DOI":"10.1039\/b820162p"},{"key":"e_1_2_13_154_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.130827"},{"key":"e_1_2_13_155_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2022.05.140"},{"key":"e_1_2_13_156_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2023.125192"},{"key":"e_1_2_13_157_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e23589"},{"key":"e_1_2_13_158_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2019.115347"},{"key":"e_1_2_13_159_1","doi-asserted-by":"publisher","DOI":"10.3390\/gels8070415"},{"key":"e_1_2_13_160_1","doi-asserted-by":"publisher","DOI":"10.1039\/c1sm05386h"},{"key":"e_1_2_13_161_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matdes.2019.108113"},{"key":"e_1_2_13_162_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cis.2021.102487"},{"key":"e_1_2_13_163_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2017.10.026"},{"key":"e_1_2_13_164_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14030659"},{"key":"e_1_2_13_165_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15051528"},{"key":"e_1_2_13_166_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2020.04.028"},{"key":"e_1_2_13_167_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2022.12.017"},{"key":"e_1_2_13_168_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951\u2010022\u201001422\u20109"},{"key":"e_1_2_13_169_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2020.111352"},{"key":"e_1_2_13_170_1","doi-asserted-by":"publisher","DOI":"10.1039\/d0nr04013d"},{"key":"e_1_2_13_171_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2007.07.002"},{"key":"e_1_2_13_172_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4TB00027G"},{"key":"e_1_2_13_173_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2021.118158"},{"key":"e_1_2_13_174_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202203751"},{"key":"e_1_2_13_175_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/5147156"},{"key":"e_1_2_13_176_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.35261"},{"key":"e_1_2_13_177_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2120968119"},{"key":"e_1_2_13_178_1","doi-asserted-by":"publisher","DOI":"10.3390\/gels9050431"},{"key":"e_1_2_13_179_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.4c01378"},{"key":"e_1_2_13_180_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2021.120618"},{"key":"e_1_2_13_181_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202302181"},{"key":"e_1_2_13_182_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2022.119492"},{"key":"e_1_2_13_183_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2017.11.113"},{"key":"e_1_2_13_184_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202001341"},{"key":"e_1_2_13_185_1","doi-asserted-by":"publisher","DOI":"10.3390\/gels7040182"},{"key":"e_1_2_13_186_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41570\u2010022\u201000420\u20107"},{"key":"e_1_2_13_187_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2008.01.057"},{"key":"e_1_2_13_188_1","doi-asserted-by":"publisher","DOI":"10.1039\/c1sm06513k"},{"key":"e_1_2_13_189_1","doi-asserted-by":"publisher","DOI":"10.1002\/ddr.21788"},{"key":"e_1_2_13_190_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2014.04.056"},{"key":"e_1_2_13_191_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.progpolymsci.2006.03.001"},{"key":"e_1_2_13_192_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.3c01162"},{"key":"e_1_2_13_193_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.progpolymsci.2019.05.001"},{"key":"e_1_2_13_194_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2004.03.019"},{"key":"e_1_2_13_195_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2025.113639"},{"key":"e_1_2_13_196_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.130342"},{"key":"e_1_2_13_197_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.macromol.4c03233"},{"key":"e_1_2_13_198_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2021.120570"},{"key":"e_1_2_13_199_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2024.102735"},{"key":"e_1_2_13_200_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.3c01133"},{"key":"e_1_2_13_201_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202407885"},{"key":"e_1_2_13_202_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2025.145395"},{"key":"e_1_2_13_203_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010025\u201056727\u20108"},{"key":"e_1_2_13_204_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2024.09.052"},{"key":"e_1_2_13_205_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201807333"},{"key":"e_1_2_13_206_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.5c01142"},{"key":"e_1_2_13_207_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2023.125528"},{"key":"e_1_2_13_208_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951\u2010023\u201002050\u20107"},{"key":"e_1_2_13_209_1","doi-asserted-by":"publisher","DOI":"10.1002\/marc.202500376"},{"key":"e_1_2_13_210_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym16141958"},{"key":"e_1_2_13_211_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2023.127940"},{"key":"e_1_2_13_212_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.132675"},{"key":"e_1_2_13_213_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2024.100993"},{"key":"e_1_2_13_214_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsapm.3c00710"},{"key":"e_1_2_13_215_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2011.10.067"},{"key":"e_1_2_13_216_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.134614"},{"key":"e_1_2_13_217_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202503551"},{"key":"e_1_2_13_218_1","doi-asserted-by":"publisher","DOI":"10.1063\/5.0037793"},{"key":"e_1_2_13_219_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.2c00179"},{"key":"e_1_2_13_220_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.3c03963"},{"key":"e_1_2_13_221_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202423227"},{"key":"e_1_2_13_222_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202312559"},{"key":"e_1_2_13_223_1","doi-asserted-by":"publisher","DOI":"10.1039\/d5tb00248f"},{"key":"e_1_2_13_224_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2024.101353"},{"key":"e_1_2_13_225_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.macromol.3c00780"},{"key":"e_1_2_13_226_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym10121317"},{"key":"e_1_2_13_227_1","doi-asserted-by":"publisher","DOI":"10.3390\/gels4010021"},{"key":"e_1_2_13_228_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.3c00041"},{"key":"e_1_2_13_229_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201302649"},{"key":"e_1_2_13_230_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.macromol.1c01115"},{"key":"e_1_2_13_231_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2022.140493"},{"key":"e_1_2_13_232_1","doi-asserted-by":"publisher","DOI":"10.1002\/app.48668"},{"key":"e_1_2_13_233_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.130266"},{"key":"e_1_2_13_234_1","doi-asserted-by":"publisher","DOI":"10.1007\/s42114\u2010024\u201000835\u20104"},{"key":"e_1_2_13_235_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201043334\u20108"},{"key":"e_1_2_13_236_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.36886"},{"key":"e_1_2_13_237_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41428\u2010020\u20100352\u20107"},{"key":"e_1_2_13_238_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtos.2021.09.002"},{"key":"e_1_2_13_239_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2025.124098"},{"key":"e_1_2_13_240_1","doi-asserted-by":"publisher","DOI":"10.1021\/bm401280z"},{"key":"e_1_2_13_241_1","doi-asserted-by":"publisher","DOI":"10.1080\/09205063.2024.2360759"},{"key":"e_1_2_13_242_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201813525"},{"key":"e_1_2_13_243_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr400559g"},{"key":"e_1_2_13_244_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.5c04355"},{"key":"e_1_2_13_245_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24163005"},{"key":"e_1_2_13_246_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2022.02.016"},{"key":"e_1_2_13_247_1","doi-asserted-by":"publisher","DOI":"10.1039\/d1ta02308j"},{"key":"e_1_2_13_248_1","doi-asserted-by":"publisher","DOI":"10.1039\/d3sm01417g"},{"key":"e_1_2_13_249_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.polymer.2019.121882"},{"key":"e_1_2_13_250_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202302551"},{"key":"e_1_2_13_251_1","doi-asserted-by":"publisher","DOI":"10.1039\/d0cs01382j"},{"key":"e_1_2_13_252_1","doi-asserted-by":"publisher","DOI":"10.3390\/gels9020102"},{"key":"e_1_2_13_253_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.202001042"},{"key":"e_1_2_13_254_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41578\u2010019\u20100148\u20106"},{"key":"e_1_2_13_255_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202202156"},{"key":"e_1_2_13_256_1","unstructured":"Y.Yao G.Wei J.Ding andW.Cui \u201c[Injectable hydrogel microspheres experimental research for the treatment of osteoarthritis] Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery \u201d37(2023):918\u2013928 https:\/\/doi.org\/10.7507\/1002\u20101892.202302105."},{"key":"e_1_2_13_257_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2010.07.028"},{"key":"e_1_2_13_258_1","doi-asserted-by":"publisher","DOI":"10.1080\/09205063.2017.1318030"},{"key":"e_1_2_13_259_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioadv.2023.213398"},{"key":"e_1_2_13_260_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2022.07.052"},{"key":"e_1_2_13_261_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym16192765"},{"key":"e_1_2_13_262_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202308599"},{"key":"e_1_2_13_263_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.129862"},{"key":"e_1_2_13_264_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202402477"},{"key":"e_1_2_13_265_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202312226"},{"key":"e_1_2_13_266_1","doi-asserted-by":"publisher","DOI":"10.1002\/btm2.10295"},{"key":"e_1_2_13_267_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2022.858656"},{"key":"e_1_2_13_268_1","doi-asserted-by":"publisher","DOI":"10.1097\/js9.0000000000002076"},{"key":"e_1_2_13_269_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2025.1606726"},{"key":"e_1_2_13_270_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2024.122424"},{"key":"e_1_2_13_271_1","doi-asserted-by":"publisher","DOI":"10.3390\/gels10040270"},{"key":"e_1_2_13_272_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202400462"},{"key":"e_1_2_13_273_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010025\u201033222\u20100"},{"key":"e_1_2_13_274_1","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201511767"},{"key":"e_1_2_13_275_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.131051"},{"key":"e_1_2_13_276_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2021.08.226"},{"key":"e_1_2_13_277_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24129939"},{"key":"e_1_2_13_278_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2022.100495"},{"key":"e_1_2_13_279_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.46450"},{"key":"e_1_2_13_280_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2022.954501"},{"key":"e_1_2_13_281_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2003.12.004"},{"key":"e_1_2_13_282_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.6b00536"},{"key":"e_1_2_13_283_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25112649"},{"key":"e_1_2_13_284_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2003.10.007"},{"key":"e_1_2_13_285_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym15173643"},{"key":"e_1_2_13_286_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.3c06706"},{"key":"e_1_2_13_287_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967\u2010026\u201008054\u20109"},{"key":"e_1_2_13_288_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsabm.5c00092"},{"key":"e_1_2_13_289_1","doi-asserted-by":"publisher","DOI":"10.2147\/ijn.S245743"},{"key":"e_1_2_13_290_1","doi-asserted-by":"publisher","DOI":"10.3390\/gels10110696"},{"key":"e_1_2_13_291_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2025.123227"},{"key":"e_1_2_13_292_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2018.11.050"},{"key":"e_1_2_13_293_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202501585"},{"key":"e_1_2_13_294_1","doi-asserted-by":"publisher","DOI":"10.1002\/macp.202200372"},{"key":"e_1_2_13_295_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2023.120667"},{"key":"e_1_2_13_296_1","doi-asserted-by":"publisher","DOI":"10.1039\/c8bm00019k"},{"key":"e_1_2_13_297_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2023.138455"},{"key":"e_1_2_13_298_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2020.08.024"},{"key":"e_1_2_13_299_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045\u2010023\u201001512\u20107"},{"key":"e_1_2_13_300_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201600124"},{"key":"e_1_2_13_301_1","doi-asserted-by":"publisher","DOI":"10.1039\/d4mh00289j"},{"key":"e_1_2_13_302_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202407885"},{"key":"e_1_2_13_303_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010023\u201001330\u2010w"},{"key":"e_1_2_13_304_1","doi-asserted-by":"publisher","DOI":"10.1124\/pharmrev.121.000349"},{"key":"e_1_2_13_305_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202302475"},{"key":"e_1_2_13_306_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202308599"},{"key":"e_1_2_13_307_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom11101518"},{"key":"e_1_2_13_308_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40744\u2010022\u201000450\u2010z"},{"key":"e_1_2_13_309_1","doi-asserted-by":"publisher","DOI":"10.3390\/gels9100808"},{"key":"e_1_2_13_310_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2025.118356"},{"key":"e_1_2_13_311_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.136819"},{"key":"e_1_2_13_312_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202501235"},{"key":"e_1_2_13_313_1","doi-asserted-by":"publisher","DOI":"10.1039\/d4mh00812j"},{"key":"e_1_2_13_314_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2024.121821"},{"key":"e_1_2_13_315_1","doi-asserted-by":"publisher","DOI":"10.26599\/frict.2025.9441095"},{"key":"e_1_2_13_316_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cocis.2024.101824"},{"key":"e_1_2_13_317_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.langmuir.4c00598"},{"key":"e_1_2_13_318_1","doi-asserted-by":"publisher","DOI":"10.3390\/lubricants12110377"},{"key":"e_1_2_13_319_1","doi-asserted-by":"publisher","DOI":"10.3390\/jox14030072"},{"key":"e_1_2_13_320_1","doi-asserted-by":"publisher","DOI":"10.3390\/ani15030404"},{"key":"e_1_2_13_321_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26051856"},{"key":"e_1_2_13_322_1","doi-asserted-by":"publisher","DOI":"10.3390\/lubricants12060186"},{"key":"e_1_2_13_323_1","doi-asserted-by":"publisher","DOI":"10.3390\/gels10060407"},{"key":"e_1_2_13_324_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2022.12.056"},{"key":"e_1_2_13_325_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2016.01.003"},{"key":"e_1_2_13_326_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2018.09.025"},{"key":"e_1_2_13_327_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2025.102203"},{"key":"e_1_2_13_328_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202301953"},{"key":"e_1_2_13_329_1","doi-asserted-by":"publisher","DOI":"10.3390\/gels11050370"},{"key":"e_1_2_13_330_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2023.100864"},{"key":"e_1_2_13_331_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010026\u201068817\u20102"},{"key":"e_1_2_13_332_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2024.101167"},{"key":"e_1_2_13_333_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2016.01.019"},{"key":"e_1_2_13_334_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2023.06.005"},{"key":"e_1_2_13_335_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.23295"},{"key":"e_1_2_13_336_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2009.04.025"},{"key":"e_1_2_13_337_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2024.101049"},{"key":"e_1_2_13_338_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.5c11890"},{"key":"e_1_2_13_339_1","doi-asserted-by":"publisher","DOI":"10.3390\/gels8010044"},{"key":"e_1_2_13_340_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2019.11.052"},{"key":"e_1_2_13_341_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265\u2010019\u201001083\u20103"},{"key":"e_1_2_13_342_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2021.05.028"},{"key":"e_1_2_13_343_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c10139"},{"key":"e_1_2_13_344_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2019.118859"},{"key":"e_1_2_13_345_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2020.02.002"},{"key":"e_1_2_13_346_1","doi-asserted-by":"publisher","DOI":"10.1177\/1947603518796550"},{"key":"e_1_2_13_347_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2022.994816"},{"key":"e_1_2_13_348_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.5c00564"},{"key":"e_1_2_13_349_1","doi-asserted-by":"publisher","DOI":"10.1177\/08853282251379151"},{"key":"e_1_2_13_350_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.10.026"},{"key":"e_1_2_13_351_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.608388"},{"key":"e_1_2_13_352_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.27305"},{"key":"e_1_2_13_353_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.02.004"},{"key":"e_1_2_13_354_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2014.01.001"},{"key":"e_1_2_13_355_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2024.12.024"},{"key":"e_1_2_13_356_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abl6449"},{"key":"e_1_2_13_357_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2025.101610"},{"key":"e_1_2_13_358_1","doi-asserted-by":"publisher","DOI":"10.34133\/research.0306"},{"key":"e_1_2_13_359_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41584\u2010024\u201001118\u20104"},{"key":"e_1_2_13_360_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2014.157"},{"key":"e_1_2_13_361_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2019.06.007"},{"key":"e_1_2_13_362_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2021.09.006"},{"key":"e_1_2_13_363_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21041306"},{"key":"e_1_2_13_364_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells8080784"},{"key":"e_1_2_13_365_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2022.101684"},{"key":"e_1_2_13_366_1","doi-asserted-by":"crossref","unstructured":"X.Yan B.Yang andY.Chen \u201cAnti\u2010Friction MSCs Delivery System Improves the Therapy for Severe Osteoarthritis \u201d (2021) 2104758 https:\/\/doi.org\/10.1002\/adma.202104758.","DOI":"10.3410\/f.741026147.793590402"},{"key":"e_1_2_13_367_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2020.06.008"},{"key":"e_1_2_13_368_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010020\u201075921\u2010w"},{"key":"e_1_2_13_369_1","doi-asserted-by":"publisher","DOI":"10.3390\/gels7020073"},{"key":"e_1_2_13_370_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2022.755260"},{"key":"e_1_2_13_371_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arabjc.2023.105488"},{"key":"e_1_2_13_372_1","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0b013e3182418d02"},{"key":"e_1_2_13_373_1","doi-asserted-by":"publisher","DOI":"10.1088\/1748\u2010605X\/ac367f"},{"key":"e_1_2_13_374_1","doi-asserted-by":"publisher","DOI":"10.1080\/08977194.2023.2227273"},{"key":"e_1_2_13_375_1","doi-asserted-by":"publisher","DOI":"10.1002\/mabi.202200516"},{"key":"e_1_2_13_376_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.52570"},{"key":"e_1_2_13_377_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.13202"},{"key":"e_1_2_13_378_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12015\u2010021\u201010252\u20105"},{"key":"e_1_2_13_379_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13770\u2010022\u201000437\u20105"},{"key":"e_1_2_13_380_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otsr.2014.07.027"},{"key":"e_1_2_13_381_1","doi-asserted-by":"publisher","DOI":"10.1039\/d5ra09529h"},{"key":"e_1_2_13_382_1","doi-asserted-by":"publisher","DOI":"10.1002\/jeo2.12016"},{"key":"e_1_2_13_383_1","doi-asserted-by":"publisher","DOI":"10.55563\/clinexprheumatol\/5lofry"},{"key":"e_1_2_13_384_1","doi-asserted-by":"publisher","DOI":"10.1055\/a\u20102865\u20101893"},{"key":"e_1_2_13_385_1","doi-asserted-by":"publisher","DOI":"10.20935\/AcadBiol7512"},{"key":"e_1_2_13_386_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11926\u2010014\u20100451\u20106"},{"key":"e_1_2_13_387_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2018.00187"},{"key":"e_1_2_13_388_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.TEB.2018.0006"},{"key":"e_1_2_13_389_1","doi-asserted-by":"publisher","DOI":"10.3390\/gels10020115"},{"key":"e_1_2_13_390_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics16040523"},{"key":"e_1_2_13_391_1","doi-asserted-by":"publisher","DOI":"10.3390\/bioengineering11010045"},{"key":"e_1_2_13_392_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2023.11.012"},{"key":"e_1_2_13_393_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym16081123"},{"key":"e_1_2_13_394_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2409729122"},{"key":"e_1_2_13_395_1","doi-asserted-by":"publisher","DOI":"10.3390\/gels12010024"},{"key":"e_1_2_13_396_1","doi-asserted-by":"publisher","DOI":"10.3390\/cimb48020211"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.71520","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adhm.71520","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.71520","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T07:49:46Z","timestamp":1788508186000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.71520"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,5]]},"references-count":395,"journal-issue":{"issue":"33","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/adhm.71520"],"URL":"https:\/\/doi.org\/10.1002\/adhm.71520","archive":["Portico"],"relation":{},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,5]]},"assertion":[{"value":"2025-12-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71520"}}