{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T08:15:57Z","timestamp":1788509757006,"version":"build-2803163510"},"reference-count":47,"publisher":"Wiley","issue":"33","license":[{"start":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:00:00Z","timestamp":1785801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:00:00Z","timestamp":1785801600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Space missions require liquid drug formulations that remain physically stable and exhibit predictable release under launch, microgravity, and handling stresses. This study examined melatonin\u2011loaded nanoemulsions flown on the MAPHEUS\u201115 sounding rocket, comparing an uncoated nanoemulsion (MN) with a chitosan\u2011coated nanoemulsion (CCN). Droplet size, polydispersity index (PDI), and zeta potential were measured at Day 0 and after spaceflight, ground vibration testing, matched ground controls, and laboratory storage. Melatonin release was quantified by dynamic dialysis and interpreted using a compartmental mass\u2010transfer model.<\/jats:p>\n                  <jats:p>Melatonin\u2011loaded nanoemulsion (MN) showed a modest, systematic increase in droplet size under all post\u2011experiment conditions, with unchanged PDI and zeta potential, consistent with time\u2011dependent coalescence and Ostwald ripening rather than a specific microgravity effect. CCN maintained essentially unchanged droplet size, PDI, and zeta potential, indicating interfacial steric stabilization by chitosan. For MN, ageing and sounding\u2011rocket exposure increased the apparent fraction of melatonin available to the aqueous phase, but normalized release profiles overlapped when scaled to the fitted maximum releasable fraction, suggesting unchanged intrinsic release kinetics. In CCN, both the accessible fraction and the release profile were preserved.<\/jats:p>\n                  <jats:p>Overall, chitosan coating enhanced dimensional and release stability, supporting interfacial polymer coatings as a strategy for robust liquid pharmaceutical formulations for future space medicine.<\/jats:p>","DOI":"10.1002\/adhm.71521","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T11:37:58Z","timestamp":1785843478000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Stability of Medicinal Nanoemulsions to Spaceflight: Insights From the StarMed Experiment"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0944-0702","authenticated-orcid":false,"given":"Modupe","family":"Adebowale","sequence":"first","affiliation":[{"name":"School of Chemical Engineering Adelaide University  Adelaide Australia"},{"name":"ARC Centre of Excellence Plants For Space Adelaide University  Adelaide Australia"},{"name":"Andy Thomas Centre For Space Resources Adelaide University  Adelaide Australia"},{"name":"School of Pharmacy University of Nottingham  Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2106-982X","authenticated-orcid":false,"given":"Nguyen Van Duc","family":"Long","sequence":"additional","affiliation":[{"name":"School of Chemical Engineering Adelaide University  Adelaide Australia"},{"name":"ARC Centre of Excellence Plants For Space Adelaide University  Adelaide Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1822-2133","authenticated-orcid":false,"given":"Philip M.","family":"Williams","sequence":"additional","affiliation":[{"name":"School of Pharmacy University of Nottingham  Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Hauslage","sequence":"additional","affiliation":[{"name":"Institute of Aerospace Medicine German Aerospace Center  Cologne Germany"},{"name":"La Trobe Institute For Moelcular Science La Trobe University  Melbourne Australia"},{"name":"School of Agriculture Biomedicine and Enviroment La Trobe University  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9494-1519","authenticated-orcid":false,"given":"Volker","family":"Hessel","sequence":"additional","affiliation":[{"name":"School of Chemical Engineering Adelaide University  Adelaide Australia"},{"name":"ARC Centre of Excellence Plants For Space Adelaide University  Adelaide Australia"},{"name":"Andy Thomas Centre For Space Resources Adelaide University  Adelaide Australia"},{"name":"School of Engineering The University of Warwick  Coventry UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,4]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12594"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.34133\/space.0251"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/frspt.2024.1456614"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.15822"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2017.05.025"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41526\u2010023\u201000271\u20106"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26082221"},{"key":"e_1_2_11_9_1","unstructured":"V. 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