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Here, we develop a nanofiber scaffold that orchestrates multimodal tissue repair through the integration of biophysical guidance and spatiotemporally controlled biochemical signaling. The scaffold features a sandwich\u2010structured architecture composed of poly(\u03b5\u2010caprolactone) (PCL) nanofibrous layers with distinct functions. A radially aligned, wound\u2010facing layer is functionalized with a center\u2010increasing gradient of keratinocyte growth factor 2\u2010loaded collagen nanoparticles, enabling rapid diffusion\u2010driven delivery to accelerate early re\u2010epithelialization. The outer layer comprises randomly oriented PCL nanofibers, ensuring mechanical support and structural stability. Between these layers, phase\u2010change material microparticles co\u2010encapsulating basic fibroblast growth factor and indocyanine green enable near\u2010infrared\u2010triggered, on\u2010demand release, sustaining local bFGF availability to support vascular reconstruction and subsequent muscle regeneration. This temporally coordinated delivery strategy couples early\u2010stage epidermal repair with prolonged support for deeper tissue regeneration. In a rat stage IV PU model, the scaffold accelerates wound closure and promotes coordinated regeneration of multiple tissue components, outperforming clinically used wound dressings. Collectively, this work establishes a nanofiber\u2010based strategy for spatiotemporally orchestrated tissue regeneration in severe wounds.<\/jats:p>","DOI":"10.1002\/adhm.71532","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T04:33:39Z","timestamp":1785904419000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Spatiotemporally Programmed Nanofiber Scaffold for Coordinated Hierarchical Multi\u2010Tissue Regeneration in Pressure Ulcers"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-4665-2467","authenticated-orcid":false,"given":"Fan","family":"Zhang","sequence":"first","affiliation":[{"name":"Beijing Laboratory of Biomedical Materials Beijing University of Chemical Technology  Beijing China"},{"name":"State Key Laboratory of Organic\u2010Inorganic Composites Beijing University of Chemical Technology  Beijing China"},{"name":"Department of 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