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Despite its clinical significance, effective treatments remain elusive. Here, we present a multifunctional nanozyme\u2010based platform, Au@Pt coated with ethanolamine\u2010functionalized poly(glycidyl methacrylate) (PGEA), yielding Au@Pt\u2010PGEA (APP), for the efficient delivery of therapeutic nerve growth factor (NGF)\u2010encoding mRNA to modulate the pathological microenvironment and restore SG function. APP exhibits glucose oxidase\u2010like catalytic activity, reactive oxygen species scavenging, oxygen generation, and electroactive properties, collectively reducing oxidative stress and improving the biochemical conditions that constrain tissue repair. When complexed with\n                    <jats:italic>Ngf<\/jats:italic>\n                    mRNA, the resulting APP\/\n                    <jats:italic>Ngf<\/jats:italic>\n                    mRNA complex (APPN) promotes endothelial angiogenic responses, induces repair\u2010associated activation of Schwann cells, and enhances neurite outgrowth in vitro. In a late\u2010stage DN murine model, APPN treatment significantly increases perfusion and sweat output, enhances neurovascular reconstruction, and restores SG structural and functional markers. Transcriptomic profiling further reveals APPN\u2010mediated shifts toward reduced inflammatory programs and enhanced pathways linked to oxidative metabolism, tissue regeneration, and peripheral nervous system development. This work establishes a combined strategy for diabetic sudomotor dysfunction through multifunctional nanozyme\u2010mediated gene therapy, underscoring its clinical potential in regenerative medicine.\n                  <\/jats:p>","DOI":"10.1002\/adhm.71541","type":"journal-article","created":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T03:20:22Z","timestamp":1786159222000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Multifunctional Nanozyme\u2010Based mRNA Delivery Platform Restores Neurovascular and Sudomotor Function in Diabetic Neuropathy"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-6077-0507","authenticated-orcid":false,"given":"Xu","family":"Guo","sequence":"first","affiliation":[{"name":"Research Center for Tissue Repair and Regeneration Affiliated to the Medical Innovation Research Department PLA General Hospital and PLA Medical School  Beijing P. R. 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