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Conventional cancer therapies are constrained by poor spatial precision in drug delivery, inadequate immunogenic cell death, and persistence of immunosuppressive M2\u2010like tumor\u2010associated macrophages. These limitations perpetuate off\u2010target toxicity, immune evasion, and tumor recurrence. In this study, we engineered an integrated therapeutic platform, HA\/IR780@Bac, through leveraging hypoxia\u2010responsive\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    to co\u2010deliver immunomodulating hyaluronic acid (HA) and the photothermal agent IR780 for synergistic cancer eradication. The system exploited bacterial tropism to achieve tumor\u2010targeted accumulation, and mediated localized photothermal ablation of tumor cells while concurrently triggered robust immunogenic cell death. This immunogenic cell death cascade\u2010initiated cancer immunogenicity and reversed immunosuppression, which was further amplified by HA\u2010driven polarization of tumor\u2010associated macrophages from pro\u2010tumoral M2 to antitumoral M1 phenotype. Therefore, the HA\/IR780@Bac system, which combined targeted delivery, photothermal effect, immunogenic cell death activation, and macrophage reprogramming, could establish a robust paradigm for synergistic tumor treatment.\n                  <\/jats:p>","DOI":"10.1002\/adhm.71549","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T03:56:32Z","timestamp":1785988592000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["An Engineered Bacterial Platform Combining Photothermal Ablation with Immunogenic Cell Death and Microenvironment Remodeling for Synergistic Tumor Therapy"],"prefix":"10.1002","volume":"15","author":[{"given":"Pandi","family":"Peng","sequence":"first","affiliation":[{"name":"State Key Laboratory of Flexible Electronics (LoFE) Xi'an Institute of Flexible Electronics and Xi'an Institute of Biomedical Materials and Engineering Northwestern Polytechnical University  Xi'an 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