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Here, we present an ionic liquid made with choline and tryptophan (CHAT) as a multifunctional excipient that enables SC injection of antibody formulations at a concentration &gt;\u00a0200\u00a0mg\/mL by simultaneously reducing viscosity, enhancing tissue permeation, and stabilizing antibodies. Notably, CHAT\u2010formulated IgG exhibited viscosities below the injectability threshold (\u223c20\u00a0cP). In murine studies, SC delivery of CHAT\u2010formulated IgG achieved significantly greater systemic exposure than saline control, with up to a 2\u2010fold increase in area under the curve (AUC). Formulation of clinically relevant anti\u2010TNF\u03b1 monoclonal antibody infliximab at &gt;200\u00a0mg\/mL with CHAT achieved near\u2010complete systemic exposure after SC administration, yielding an absolute bioavailability of \u223c99% compared to \u223c62% with saline. Mechanistically, CHAT disrupted collagen in the extracellular matrix, improving SC tissue penetration and accelerating antibody uptake (\u223c4\u00d7 faster clearance from the injection site), and preserved antigen\u2010binding capacity after serum exposure (100% retention vs. \u223c50% with saline). CHAT exhibited excellent biocompatibility with no histopathological or biochemical indications of toxicity in treated animals. Together, these results position CHAT as a single\u2010component platform for high\u2010dose, low\u2010volume SC delivery of monoclonal antibodies.<\/jats:p>","DOI":"10.1002\/adhm.71550","type":"journal-article","created":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T05:39:23Z","timestamp":1787377163000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Enhancing Bioavailability of Ultra\u2010High Concentration Antibody Formulations Using Ionic Liquids"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0173-5434","authenticated-orcid":false,"given":"Anujan","family":"Ramesh","sequence":"first","affiliation":[{"name":"Harvard John A. 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