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Here, a\n                    <jats:italic>\u03b3<\/jats:italic>\n                    \u2010ray\u2010responsive dynamic covalent polymeric radioprotectant, engineered by integrating phenylboronic acid (PBA)\u2010functionalized polymeric micelles with the potent antioxidants epigallocatechin\u20103\u2010gallate (EGCG) and curcumin (Cur), is developed to provide efficient systemic protection. The architecture of this dynamic covalent polymeric radioprotectant is stabilized by reversible dynamic covalent linkages between the PBA moieties and the catechol groups of EGCG, ensuring robust persistence during systemic circulation and precise release within the radiation\u2010triggered microenvironment. Furthermore, the structural affinity between EGCG and Cur facilitates efficient \u03c0\u2013\u03c0 stacking interactions, enabling the synchronized encapsulation and triggered release of the dual\u2010drug cargo. Compared to individual antioxidant treatments, this dynamic covalent system exhibits superior efficacy in scavenging reactive oxygen species (ROS), promoting cell proliferation, and inhibiting apoptosis. In vivo assessments further confirm that this radioprotectant affords comprehensive systemic protection, effectively mitigating radiation\u2010related physiological damage and enhancing overall survival by orchestrating endogenous antioxidant responses. Given that numerous molecules with radioprotective potential possess diol or catechol motifs, this modular and responsive design offers a versatile framework for on\u2010demand radioprotection, greatly promising for clinical translation.\n                  <\/jats:p>","DOI":"10.1002\/adhm.71561","type":"journal-article","created":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T05:35:31Z","timestamp":1786426531000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A\n                    <i>\u03b3<\/i>\n                    \u2010Ray\u2010Responsive Dynamic Covalent Polymeric Radioprotectant for Efficient Radiation Injury Treatment"],"prefix":"10.1002","volume":"15","author":[{"given":"Yingyi","family":"Ning","sequence":"first","affiliation":[{"name":"State Key Laboratory of Advanced Medical Materials and Devices Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine Key Laboratory of 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