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Herein, a dissolvable microneedle platform based on Prussian blue (PB) nanoparticles was developed to locally deliver curcumin (Cur) or edaravone (EDA) into injured brain tissue through a transiently disrupted blood\u2013brain barrier. The microneedles were fabricated from hyaluronic acid\/carboxymethyl chitosan (HCMN) using a low\u2010temperature multilayer drying process while maintaining the structural integrity of PB nanoparticles. Acting as both ROS\u2010scavenging nanozymes and drug carriers, PB nanoparticles enabled flexible incorporation of different therapeutic agents within the same delivery platform. In vitro and in vivo studies showed that HCMN\/PB\/Cur exhibited greater anti\u2010inflammatory activity under relatively mild pathological conditions, whereas HCMN\/PB\/EDA displayed stronger antioxidant capacity under higher oxidative stress. These results suggest that different therapeutic formulations may be preferable under distinct pathological conditions while preserving the same delivery platform. This microneedle system provides a localized delivery approach and offers greater flexibility for formulation selection in the treatment of acute TBI.<\/jats:p>","DOI":"10.1002\/adhm.71565","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T04:29:31Z","timestamp":1788409771000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Modular Prussian Blue Nanozyme\u2010Based Microneedle Platform With Flexible Therapeutic Formulations for Localized Treatment of Traumatic Brain Injury"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-8022-8863","authenticated-orcid":false,"given":"Xiang","family":"Wang","sequence":"first","affiliation":[{"name":"School of Medical Science and Engineering Beijing Institute of Technology  Beijing 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