{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T23:14:33Z","timestamp":1789168473003,"version":"build-2803163510"},"reference-count":47,"publisher":"Wiley","issue":"34","license":[{"start":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T00:00:00Z","timestamp":1786406400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T00:00:00Z","timestamp":1786406400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22175130"],"award-info":[{"award-number":["22175130"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006606","name":"Natural Science Foundation of Tianjin Municipality","doi-asserted-by":"publisher","award":["24JCQNJC01740"],"award-info":[{"award-number":["24JCQNJC01740"]}],"id":[{"id":"10.13039\/501100006606","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Ferroptosis is an iron\u2010dependent form of regulated cell death that has emerged as one of the mechanisms underlying cisplatin\u2010induced nephrotoxicity. Here, we report an iron\u2010chelating polymeric micelle for controlled cisplatin activation and ferroptosis suppression to address the above issue. The block copolymer, methoxyl polyethylene glycol\u2010poly(glutamic acid) (mPEG\u2010PGlu) was coupled with an iron chelator, deferiprone (Dfp) to generate the tailored amphiphilic conjugate, mPEG\u2010P(Glu\u2010Dfp) that could coordinate with activated cisplatin and self\u2010assemble into micelles (Pt@M\n                    <jats:sub>Dfp<\/jats:sub>\n                    ). The cisplatin\u2010loaded mPEG\u2010PGlu micelles (Pt@M\n                    <jats:sub>Glu<\/jats:sub>\n                    ) and free cisplatin were employed as controls. Upon endocytosis, the intracellular labile iron could replace cisplatin due to the higher affinity between Dfp and Fe\n                    <jats:sup>2+<\/jats:sup>\n                    . This coordination exchange resulted in controlled cargo release and suppressed lipid peroxidation and inflammation in renal tubular cells (HK\u20102). The proof\u2010of\u2010concept was also validated in the subcutaneous 4T1 mouse breast tumor model using plasma and urine biomarkers of ferroptosis, inflammation, and renal injury as the indices, which concurred well with the histological staining of kidney tissue and fibrosis assessment. Moreover, due to the controlled cargo activation, Pt@M\n                    <jats:sub>Dfp<\/jats:sub>\n                    significantly enhanced the in vivo antitumor efficacy compared to Pt@M\n                    <jats:sub>Glu<\/jats:sub>\n                    and free cisplatin. Collectively, the coordination exchange approach is promising in controlled delivery of cisplatin for efficacy enhancement.\n                  <\/jats:p>","DOI":"10.1002\/adhm.71575","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T05:44:14Z","timestamp":1786513454000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Amelioration of Cisplatin Nephrotoxicity by Fe\u2013Pt Coordination Exchange\u2010Triggered Ferroptosis Suppression"],"prefix":"10.1002","volume":"15","author":[{"given":"Tiantian","family":"Chen","sequence":"first","affiliation":[{"name":"School of Pharmaceutical Science and Technology Tianjin Key Laboratory for Modern Drug Delivery and High Efficiency Faculty of Medicine Tianjin University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panyu","family":"Du","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical 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