{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T05:27:13Z","timestamp":1786685233534,"version":"build-2736575974"},"reference-count":40,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2402801"],"award-info":[{"award-number":["2022YFC2402801"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32571577"],"award-info":[{"award-number":["32571577"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32301132"],"award-info":[{"award-number":["32301132"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The complex phytochemical composition of Traditional Chinese Medicines (TCM) like Ligusticum chuanxiong offers multi\u2010target therapeutic potential, yet their intracellular mechanisms remain largely undefined due to a lack of suitable investigative tools. We report a mitochondria\u2010targeted nanoformulation (NSCE) created by loading Chuanxiong extract (CE) into amino\u2010functionalized mesoporous silica nanoparticles (NS). We show that the adsorbed extract components unexpectedly confer mitochondrial tropism to the simple amino\u2010functionalized silica nanoparticles, a function not inherent to the unmodified carrier. In vitro, NSCE selectively localizes to the mitochondria of cardiomyocyte, mitigating oxidative stress and dysfunction more effectively than free CE. In a rat model of ischemia\/reperfusion injury, intramyocardial NSCE injection reduces infarct size and improves cardiac function. Mechanistically, NSCE synergistically modulates p53 and PI3K\/AKT pathways to suppress apoptosis and oxidative stress, an action linked to its delivery of 52 identified bioactive constituents. This work introduces a paradigm where a complex herbal extract can functionalize a simple nanocarrier for organelle\u2010specific delivery, offering a tractable strategy to dissect and harness the multitarget pharmacology of traditional medicines.<\/jats:p>","DOI":"10.1002\/adhm.71579","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T04:35:47Z","timestamp":1786682147000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Chuanxiong Extract\u2010Decorated Mitochondria\u2010Targeted Nanocarriers Attenuate Infarct Injury by Restoring Mitochondrial Homeostasis and Blocking Oxidative Cascade"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-3376-8162","authenticated-orcid":false,"given":"Qinran","family":"Chen","sequence":"first","affiliation":[{"name":"Biomaterials Research Center School of Biomedical Engineering Southern Medical University Guangzhou Guangdong China"},{"name":"Integrated Hospital of Traditional Chinese Medicine Southern Medical University Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7790-0130","authenticated-orcid":false,"given":"Yaxi","family":"He","sequence":"additional","affiliation":[{"name":"Biomaterials Research Center School of Biomedical Engineering Southern Medical University Guangzhou Guangdong China"},{"name":"Integrated Hospital of Traditional Chinese Medicine Southern Medical University Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3298-9074","authenticated-orcid":false,"given":"Guangbing","family":"Luo","sequence":"additional","affiliation":[{"name":"Integrated Hospital of Traditional Chinese Medicine Southern Medical University Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5997-6372","authenticated-orcid":false,"given":"Xin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering School of Basic Medical Sciences Southern Medical University Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5901-2742","authenticated-orcid":false,"given":"Jie","family":"Shen","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering School of Basic Medical Sciences Southern Medical University Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0230-4605","authenticated-orcid":false,"given":"Danfeng","family":"Wu","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering School of Basic Medical Sciences Southern Medical University Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4523-7389","authenticated-orcid":false,"given":"Yutong","family":"He","sequence":"additional","affiliation":[{"name":"Department of Anatomy School of Basic Medical Sciences Guangzhou Medical University Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-8636-9471","authenticated-orcid":false,"given":"Bingyu","family":"Zhao","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering School of Basic Medical Sciences Southern Medical University Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6547-1490","authenticated-orcid":false,"given":"Leyu","family":"Wang","sequence":"additional","affiliation":[{"name":"Biomaterials Research Center School of Biomedical Engineering Southern Medical University Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6638-4836","authenticated-orcid":false,"given":"Renjie","family":"Qiu","sequence":"additional","affiliation":[{"name":"Integrated Hospital of Traditional Chinese Medicine Southern Medical University Guangzhou Guangdong China"},{"name":"Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering School of Basic Medical Sciences Southern Medical University Guangzhou Guangdong 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