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In this study, we developed a multifunctional Janus\u2010structured scaffold (PLGA\u2010PCL+CS+Cu\u2010TA NS+P2, PCTP) by integrating chitosan (CS) electrospun fibers with PLGA\u2010PCL coaxial electrospun fibers loaded with tannic acid (TA)\u2010copper nanosheets (NSs). The NSs were loaded with PTHrP\u20102 to enhance bioactivity. The unique \u201ccore\u2013shell\u201d design protects the drug and ensures efficient release. The Janus architecture rationally manages wound exudate while maintaining a moist microenvironment conducive to healing. Moreover, PCTP exhibits excellent mechanical properties and sustained release kinetics. Its potent antioxidant and antibacterial activities effectively scavenge reactive oxygen species, protect mitochondrial integrity, and delay cellular senescence. Crucially, PCTP accelerates the regeneration of dermal fibers and epidermis structures while promoting concurrent neurogenesis and angiogenesis, thereby restoring both structural integrity and functional competence. In diabetic rat models, PCTP significantly enhanced vascularization, collagen deposition, and inflammation modulation. Collectively, this multifunctional scaffold represents a promising therapeutic strategy for achieving integrated structural and functional skin regeneration in the challenging diabetic milieu.<\/jats:p>","DOI":"10.1002\/adhm.71588","type":"journal-article","created":{"date-parts":[[2026,8,16]],"date-time":"2026-08-16T12:41:08Z","timestamp":1786884068000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Multifunctional Janus Membrane Promotes Neurovascular Network Regeneration for Diabetic Wound Healing"],"prefix":"10.1002","volume":"15","author":[{"given":"Zouwei","family":"Li","sequence":"first","affiliation":[{"name":"Department of Orthopedics Zhongnan Hospital of Wuhan University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renxin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Zhongnan Hospital of Wuhan University  Wuhan 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