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Herein, we design a ternary coordination polymer (Fe\u2010SASP\/ART) that overcomes these limitations while promoting keratinocyte proliferation. The first formed Fe\u2010sulfasalazine (SASP) precursors exhibit photothermal and photodynamic properties via ligand\u2010to\u2010metal charge transfer (LMCT). Artemisinin (ART) serves as coordinating ligands and structural inducers, transforming amorphous precursors into crystalline frameworks. The ART\u2010directed architecture enables oxygen\u2010independent carbon\u2010centered radical generation via Fe\n                    <jats:sup>2<\/jats:sup>\n                    <jats:sup>+<\/jats:sup>\n                    \u2010catalyzed ART cleavage (Fe\n                    <jats:sup>2+<\/jats:sup>\n                    generated from LMCT), establishing a dual\u2010channel energy dissipation pathway that enhances photothermal and photodynamic performance. Notably, the iron\u2010mediated activation of ART establishes a\u00a0self\u2010sustaining Fe\n                    <jats:sup>3+<\/jats:sup>\n                    \/Fe\n                    <jats:sup>2+<\/jats:sup>\n                    redox cycle, driving prolonged radical production post\u2010irradiation for sustained antibacterial effect.\u00a0The nanoplatform achieves 69.5% bactericidal efficacy against\n                    <jats:italic>P. acnes<\/jats:italic>\n                    upon NIR irradiation, suppresses pro\u2010inflammatory cytokines via SASP, and promotes keratinocyte proliferation (120.9% viability) through hormesis. Ex vivo studies confirm efficient follicular accumulation of the nanoplatform with controlled penetration depth. In mouse acne models, a single topical treatment with NIR irradiation elicits sustained lesion resolution over 5 days, with potent therapeutic efficacy, anti\u2010inflammatory effects, and excellent biocompatibility. This work offers a promising paradigm for safe and effective acne management.\n                  <\/jats:p>","DOI":"10.1002\/adhm.71591","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T04:45:58Z","timestamp":1786682758000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Artemisinin\u2010Directed Crystallization of an Iron\u2010Sulfasalazine Coordination Polymer for Acne Synergistic Phototherapy With Sustained Antibacterial and Pro\u2010Regenerative Effects"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6379-2373","authenticated-orcid":false,"given":"Jian","family":"Chen","sequence":"first","affiliation":[{"name":"Henan Key Laboratory of Nanocomposite and Applications Institute of Nanostructured Functional Materials Huanghe Science and Technology College  Zhengzhou Henan 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