{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T07:02:40Z","timestamp":1789714960384,"version":"4.0.1"},"reference-count":56,"publisher":"Wiley","issue":"35","license":[{"start":{"date-parts":[[2026,8,16]],"date-time":"2026-08-16T00:00:00Z","timestamp":1786838400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,16]],"date-time":"2026-08-16T00:00:00Z","timestamp":1786838400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005762","name":"National Taiwan University Hospital","doi-asserted-by":"publisher","award":["114\u2010SS0053"],"award-info":[{"award-number":["114\u2010SS0053"]}],"id":[{"id":"10.13039\/501100005762","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    This study investigates the feasibility and therapeutic effectiveness of a novel drug\u2011loaded parylene electrode prototype (PEP) designed to reduce inflammation and hearing loss associated with cochlear implantation (CI). The porous PEP was fabricated using vapor\u2011phase sublimation and deposition, producing an interconnected structure with 20\u201330\u00a0\u00b5m pores and mechanical flexibility suitable for intracochlear placement. Dexamethasone was incorporated into the device (Dex\/PEP), and in vitro characterization using ELISA and spectrophotometry demonstrated controlled first\u2011order release kinetics. Guinea pigs underwent microsurgical implantation of PEPs, with accurate positioning confirmed by micro\u2011CT imaging. Auditory outcomes were assessed through auditory brainstem response (ABR) measurements, and cochlear tissues were examined histologically to evaluate inflammatory cell infiltration and cytokine expression. The Dex\/PEP device exhibited biosafety comparable to traditional silicone electrodes and provided sustained drug release. Animals receiving Dex\/PEP showed significantly improved ABR thresholds at 1 and 4 weeks compared with blank PEP controls (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.05), indicating reduced inflammation\u2011induced hearing loss. Histological analysis further revealed diminished inflammatory cell infiltration and markedly decreased TNF\u2011\u03b1 expression at the round window membrane (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.001). These findings support the drug\u2011loaded PEP as a promising targeted delivery platform for reducing cochlear inflammation and preserving hearing following CI.\n                  <\/jats:p>","DOI":"10.1002\/adhm.71593","type":"journal-article","created":{"date-parts":[[2026,8,16]],"date-time":"2026-08-16T12:42:44Z","timestamp":1786884164000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Novel Drug\u2010Loaded Porous Parylene Electrode for Targeted Anti\u2010Inflammatory Therapy and Hearing Preservation in Cochlear Implantation"],"prefix":"10.1002","volume":"15","author":[{"given":"Chi\u2010Chieh","family":"Chang","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery National Taiwan University Hospital  Taipei 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