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Although several clinical, neuroimaging, and biomarker\u2010based diagnostic approaches are available for NDs, their limited sensitivity for early\u2010stage detection, disease specificity, and prediction of disease progression continue to present significant clinical challenges, often resulting in delayed diagnosis and therapeutic intervention. According to previously published works, the preliminary pathological feature of such disorders is mitochondrial dysfunction. This may lead to elevated oxidative stress, impaired mitophagy, unbalanced mitochondrial function, and bioenergetic failure. This review examines how mitochondria\u2010targeted nanotherapeutic approaches can overcome these pathological barriers and improve therapeutic outcomes in aging\u2010associated neurodegeneration. Targeted delivery of drug\u2010loaded nanocarriers, such as gene\u2010delivery, lipid\u2010based, metallic, and polymeric nanoparticles, has emerged as a potential platform to deliver medication directly to defective mitochondria. It may increase mitochondrial biogenesis, maintain redox balance, and protect against neuronal degeneration. This work incorporates disease\u2010specific mitochondrial pathology with current progress in targeted nanotherapeutics, age\u2010associated delivery barriers, clinical revolution, and emerging artificial intelligence (AI)\u2010enabled precision therapeutic approaches. Mitochondria\u2010targeted nanotherapeutics depict a potential disease\u2010modifying strategy for aging\u2010related NDs. However, further advancements in targeting efficacy, scalable production, long\u2010term safety, and clinical validation can facilitate a successful clinical revolution.<\/jats:p>","DOI":"10.1002\/adhm.71594","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T05:26:00Z","timestamp":1787203560000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Mitochondria\u2010Targeted Nanotherapies in Aging Neurodegenerative Disorders: Emerging Prospects and Clinical Potential"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2557-3115","authenticated-orcid":false,"given":"Dnyandev G.","family":"Gadhave","sequence":"first","affiliation":[{"name":"Department of Pharmaceutics Dattakala Shikshan Sanstha's Dattakala College of Pharmacy (Affiliated to Savitribai Phule Pune University)  Pune Maharashtra India"},{"name":"College of Pharmacy &amp; Health Sciences St. 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