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By encapsulating\n                    <jats:bold>OR6<\/jats:bold>\n                    into functionalized nanoparticles (d\n                    <jats:bold>OR6<\/jats:bold>\n                    \u2010NPs), a remarkable near\u2010infrared\u2010II (NIR\u2010II) absorption at 1056\u00a0nm and photothermal conversion efficiency (PCE) of 84.66% are achieved. To overcome the limitations of passive tumor targeting, a bioorthogonal \u201ctag\u2010and\u2010target\u201d strategy is developed using metabolic glycan labeling and copper\u2010free click reaction. This approach significantly enhanced photothermal therapeutic efficacy both in vitro and in vivo. The d\n                    <jats:bold>OR6<\/jats:bold>\n                    \u2010NPs induce significant cytotoxicity of cancer cells under 1064\u00a0nm laser irradiation, leading to nearly complete tumor suppression in a xenograft model while maintaining excellent biocompatibility and systemic safety. This work not only highlights olympicenyl radicals as a new class of PTAs but also establishes a robust click\u2010reaction\u2010based platform for precision cancer therapy.\n                  <\/jats:p>","DOI":"10.1002\/adhm.71597","type":"journal-article","created":{"date-parts":[[2026,8,16]],"date-time":"2026-08-16T12:36:28Z","timestamp":1786883788000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Targeted NIR\u2010II Photothermal Therapy Enabled by Bioorthogonal Click Reaction With Olympicenyl Radical Nanoparticles"],"prefix":"10.1002","volume":"15","author":[{"given":"Mingzhe","family":"Wang","sequence":"first","affiliation":[{"name":"Institute of Molecular Plus Department of Chemistry and Haihe Laboratory of Sustainable Chemical Transformations Tianjin University  Tianjin 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