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Conventional polymerase chain reaction (PCR) offers high sensitivity but is hindered by bulky equipment, long processing times, and the need for technical expertise, limiting its point\u2010of\u2010care testing (POCT) applications. To overcome these constraints, we developed an innovative photonic PCR system utilizing the plasmonic photothermal effect of a gold nanofilm to accelerate the amplification process. This system integrates a lateral flow assay (LFA) for the streamlined visual detection of FITC\u2010 and biotin\u2010labeled Seoul orthohantavirus (SEOV) amplicons using gold nanoparticle\u2010conjugated antibodies. By synergizing photonic PCR with LFA, we achieved real\u2010time\u2010like detection of target products within 15\u00a0min (excluding the extraction step). This integrated platform demonstrates a limit of detection (LOD) of 150 copies\/mL of the template genome, significantly enhancing diagnostic sensitivity. Our design prioritizes simplicity and efficiency, eliminating the requirement for sophisticated instrumentation or extensive operator training. Given its rapid processing, cost\u2010effectiveness, and high sensitivity, this photonic PCR\u2010LFA system represents a compelling solution for diverse diagnostic applications, including clinical diagnostics, environmental monitoring, and field\u2010based testing. This advancement underscores the potential of plasmon\u2010driven materials in transforming next\u2010generation molecular POCT platforms.<\/jats:p>","DOI":"10.1002\/adhm.71600","type":"journal-article","created":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T05:38:26Z","timestamp":1787377106000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Plasmon\u2010Driven Gene Amplification\u2010Integrated Lateral Flow Assay for Ultrafast Diagnosis of Seoul Orthohantavirus"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6261-9309","authenticated-orcid":false,"given":"Sung Eun","family":"Seo","sequence":"first","affiliation":[{"name":"SKKU Advanced Institute of Nano Technology (SAINT) Sungkyunkwan University Suwon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2691-0910","authenticated-orcid":false,"given":"Kyung 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