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In the Ross procedure, the patient's own pulmonary valve is placed in aortic position, forming a pulmonary autograft. The main limitation of the intervention is postoperative dilatation under systemic blood pressures, compromising its durability. Existing polymer textiles can limit diameter expansion, but restrict physiological wall motion and cause vascular atrophy of the underlying tissue. Here, a mechanocompatible external support was developed and evaluated, stabilizing autograft diameter while preserving arterial compliance. Biodegradable tubular scaffolds were fabricated by electrospinning polycaprolactone and elastin polymer blends. As a preclinical proof\u2010of\u2010concept, supported and unsupported pulmonary arteries were transplanted into rats' abdominal aortas to mimic the mechano\u2010biological conditions of the Ross procedure. Micro\u2010computed tomography showed maintenance of wall diameter over eight weeks, whereas unsupported autografts exhibited significant dilatation. Histological analysis and mechanical testing highlighted benign adaptation in both the supported and unsupported autografts. A tailored degradation study further revealed how the physiological environment influences the mechanical integrity of the tissue\u2013scaffold complex. Overall, the electrospun structures present a promising strategy to prevent dilatation while enabling autograft remodeling, offering a translational pathway to improve surgical outcomes in a cardiovascular\u00a0context.<\/jats:p>","DOI":"10.1002\/adhm.71601","type":"journal-article","created":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T05:47:48Z","timestamp":1787377668000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Electrospinning a Mechanocompatible External Support for the Ross Procedure"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9218-2195","authenticated-orcid":false,"given":"Thibault","family":"Vervenne","sequence":"first","affiliation":[{"name":"Biomechanics, Department of Mechanical Engineering KU Leuven Leuven Belgium"},{"name":"Smart Polymeric Biomaterials KU Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amber","family":"Hendrickx","sequence":"additional","affiliation":[{"name":"Cardiac Surgery, Department of Cardiovascular Sciences KU Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6196-7062","authenticated-orcid":false,"given":"Margaux","family":"Schols","sequence":"additional","affiliation":[{"name":"Cardiac Surgery, Department of Cardiovascular Sciences KU Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8428-2302","authenticated-orcid":false,"given":"Filip","family":"Rega","sequence":"additional","affiliation":[{"name":"Cardiac Surgery, Department of Cardiovascular Sciences KU Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7374-8912","authenticated-orcid":false,"given":"Nele","family":"Famaey","sequence":"additional","affiliation":[{"name":"Biomechanics, Department of Mechanical Engineering KU Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4339-8827","authenticated-orcid":false,"given":"Arn","family":"Mignon","sequence":"additional","affiliation":[{"name":"Smart Polymeric Biomaterials KU Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,21]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.09.595"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.829120"},{"key":"e_1_2_10_4_1","doi-asserted-by":"crossref","unstructured":"H. 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