{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T05:51:27Z","timestamp":1791438687155,"version":"4.3.3"},"reference-count":42,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,16]],"date-time":"2026-08-16T00:00:00Z","timestamp":1786838400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,16]],"date-time":"2026-08-16T00:00:00Z","timestamp":1786838400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    This study reports a multifunctional dental gel of calcium peroxide\u2010amorphous calcium carbonate phosphate (CaO\n                    <jats:sub>2<\/jats:sub>\n                    \u2010ACCP), capable of synergistically repairing damaged dentin, tooth\u2010whitening, and exerting antibacterial activity. The CaO\n                    <jats:sub>2<\/jats:sub>\n                    nanoparticles react with water in saliva, releasing Ca\n                    <jats:sup>2+<\/jats:sup>\n                    , OH\n                    <jats:sup>\u2212<\/jats:sup>\n                    , and reactive oxygen species (ROS). The thus\u2010generated alkaline environment and the released Ca\n                    <jats:sup>2+<\/jats:sup>\n                    ions promote the conversion of the ACCP gel into hydroxyapatite (HAP), which is critical for remineralizing damaged dentin and restoring its microhardness (from 0.1\u00a0GPa for acid\u2010etched to 2.0\u00a0GPa for remineralized). On the other hand, the gel provides an ultralarge surface for concurrent adsorption of ROS and pigment molecules, enabling efficient stain removal and rapid tooth whitening within 12\u00a0h. Simultaneously, the gel effectively suppresses pathogenic bacteria growth (almost 100% sterilized within 24\u00a0h) and prevents caries. Through the mechanisms of \u201cROS confinement buffer\u201d and \u201cCa\n                    <jats:sup>2+<\/jats:sup>\n                    \u2010driven positive feedback synergy,\u201d an effect of \u201c1+1&gt;2\u201d is achieved. This study demonstrates synergistic intervention across the disease\u2010aesthetic spectrum, promising a gentle and effective solution for comprehensive oral healthcare.\n                  <\/jats:p>","DOI":"10.1002\/adhm.71607","type":"journal-article","created":{"date-parts":[[2026,8,16]],"date-time":"2026-08-16T12:44:39Z","timestamp":1786884279000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Unifying Dental Gel for Enamel\u2010Remineralization, and Whitening Effects"],"prefix":"10.1002","author":[{"given":"Hong","family":"Yue","sequence":"first","affiliation":[{"name":"Department of Materials Science and Engineering City University of Hong Kong  Hong Kong SAR China"},{"name":"Hong Kong Branch of National Precious Metals Material Engineering Research Center City University of Hong Kong  Hong Kong SAR China"},{"name":"Centre For Advanced Structural Materials City University of Hong Kong Shenzhen Research Institute  Shenzhen China"},{"name":"Center of Super\u2010Diamond and Advanced Films (COSDAF) City University of Hong Kong  Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinxue","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Engineering City University of Hong Kong  Hong Kong SAR China"},{"name":"Hong Kong Branch of National Precious Metals Material Engineering Research Center City University of Hong Kong  Hong Kong SAR China"},{"name":"Centre For Advanced Structural Materials City University of Hong Kong Shenzhen Research Institute  Shenzhen China"},{"name":"Center of Super\u2010Diamond and Advanced Films (COSDAF) City University of Hong Kong  Hong Kong SAR China"},{"name":"Department of Mechanical Engineering City University of Hong Kong  Hong Kong SAR 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