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Herein, we report efficient ferritin\u2010mimetic nanominerals engineered via a small molecule\u2010mediated iron phosphate mineralization strategy, which emulates the natural iron storage and release processes to selectively trigger tumor ferroptosis. Using two ferroptosis inducers, palbociclib and Fin56, as model small molecules, the resulting nanominerals exhibit uniform size distribution, robust stability, and 72% iron incorporation efficiency, enabling precisely controlled ferrous ion release and dual\u2010drug co\u2010delivery within tumor tissues to achieve a triple amplification of ferroptosis. The amplified ferroptosis response further elicits a potent antitumor immune effect through immunogenic cell death, ultimately resulting in remarkable therapeutic efficacy with minimal side effects both in vitro and in vivo. This small molecule\u2010mediated iron phosphate mineralization strategy offers a superior alternative to traditional coordination self\u2010assembly for nanomedicine construction through enhanced programmability, improved stability and higher iron loading, thereby advancing ferroptosis\u2010related combination therapy and synergistic therapy.<\/jats:p>","DOI":"10.1002\/adhm.71609","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:27:03Z","timestamp":1787027223000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ferritin\u2010Inspired Mineralized Iron Phosphate Nanominerals for Precision Ferroptosis\u2013Immunotherapy via Controlled Iron Storage and Release"],"prefix":"10.1002","volume":"15","author":[{"given":"Hanyu","family":"Zhang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Bio\u2010fibers and Eco\u2010textiles Institute of Biochemical Engineering College of Materials Science and Engineering Qingdao University  Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongsheng","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Medicinal Molecule Science and Pharmaceutics Engineering Ministry of Industry and Information Technology School of Chemistry and Chemical Engineering Beijing Institute of Technology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Wu","sequence":"additional","affiliation":[{"name":"Qingdao Women and Children's Hospital Qingdao University  Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1511-4599","authenticated-orcid":false,"given":"Yongxin","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bio\u2010fibers and Eco\u2010textiles Institute of Biochemical Engineering College of Materials Science and Engineering 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