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Although nanozyme\u2010based wound healing strategies have been widely explored, most of them rely on multiple components to overcome multi\u2010stage healing barriers, which often makes the system complex and difficult to achieve stage\u2010adaptive functions. Here, we developed a simple and stage\u2010adaptive platform (MF127) by integrating a thermosensitive hydrogel with high\u2010content 1T phase\u2010engineered MoSe\n                    <jats:sub>2<\/jats:sub>\n                    nanosheets (1T\u2010MoSe\n                    <jats:sub>2<\/jats:sub>\n                    ) as the only active nanozyme component. The MF127 hydrogel exhibits injectability, sprayability, and rapid sol\u2010gel transition, enabling conformal coverage of irregular wounds. Under near\u2010infrared (NIR) and ultrasound (US) stimulation, MF127 acts as a sonosensitizer for ROS generation through photothermal\u2010enhanced sonocatalytic effects, eliminating both planktonic bacteria and biofilms. Under non\u2010stimulated conditions, MF127 exhibits antioxidant enzyme\u2010like activity, reducing excessive oxidative stress and promoting M2\u2010like macrophage phenotype modulation. Furthermore, MF127 also actively promotes wound healing through fibroblast activation and extracellular matrix (ECM) remodeling in vivo. This work presents a simplified, stage\u2010adaptive platform that integrates antibacterial action, antioxidation, and regeneration to meet the needs of infected diabetic wound management.\n                  <\/jats:p>","DOI":"10.1002\/adhm.71610","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T04:33:07Z","timestamp":1788755587000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Stage\u2010Adaptive Therapy for Infected Diabetic Wound Through Photothermal\u2010Enhanced Sonocatalytic Antibacterial and Repair Activation"],"prefix":"10.1002","volume":"15","author":[{"given":"Yu\u2010Sen","family":"Zhang","sequence":"first","affiliation":[{"name":"Center For Evidence\u2010Based and Translational Medicine Zhongnan Hospital of Wuhan University  Wuhan 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