{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T07:02:43Z","timestamp":1789714963428,"version":"4.0.1"},"reference-count":37,"publisher":"Wiley","issue":"35","license":[{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005046","name":"Natural Science Foundation of Heilongjiang Province","doi-asserted-by":"publisher","award":["LH2024H074"],"award-info":[{"award-number":["LH2024H074"]}],"id":[{"id":"10.13039\/501100005046","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017961","name":"Health Commission of Heilongjiang Province","doi-asserted-by":"publisher","award":["20240909010090"],"award-info":[{"award-number":["20240909010090"]}],"id":[{"id":"10.13039\/100017961","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Dense stromal barriers and lysosomal sequestration severely restrict the extracellular transport and intracellular trafficking of nanomedicines in pancreatic cancer, while the robust glutathione (GSH)\u2010dependent antioxidant defense further compromises therapeutic efficacy. Here, we developed a proton sponge\u2010enabled dual\u2010driven nanomotor, HA\/PEI\u2010DOX@MMSN@Pt (HPDMP), for MRI\u2010guided pancreatic cancer therapy. The asymmetric Pt domain generated near\u2010infrared (NIR)\u2010induced self\u2010thermophoretic motion as the principal externally controllable driving mechanism, whereas endogenous H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    provided auxiliary catalytic propulsion, together facilitating nanomotor transport through the dense tumor stroma and enhancing intratumoral penetration. Following cellular uptake, PEI\u2010mediated proton sponge activity facilitated lysosomal escape and increased cytosolic DOX availability. Meanwhile, tumor\u2010microenvironment\u2010responsive degradation of the Mn\u2010doped framework consumed GSH and released Mn\n                    <jats:sup>2+<\/jats:sup>\n                    , thereby enhancing reactive oxygen species (ROS) generation, ferroptosis\u2010associated oxidative damage, and T\n                    <jats:sub>1<\/jats:sub>\n                    \u2010weighted MRI contrast. HA modification further promoted CD44\u2010mediated tumor targeting. Under NIR irradiation, HPDMP achieved pronounced antitumor efficacy with favorable biosafety. This work provides a barrier\u2010oriented nanomotor strategy for pancreatic cancer therapy.\n                  <\/jats:p>","DOI":"10.1002\/adhm.71615","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:41:21Z","timestamp":1787028081000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Proton Sponge\u2010Enabled Dual\u2010Driven Nanomotors for MRI\u2010Guided Tumor\u2010Penetrating Synergistic Therapy of Pancreatic Cancer"],"prefix":"10.1002","volume":"15","author":[{"given":"Shuai","family":"He","sequence":"first","affiliation":[{"name":"Department of Molecular Imaging School of Medical Technology Qiqihar Medical University  Qiqihar Heilongjiang P. R. 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6188-1347","authenticated-orcid":false,"given":"Liguo","family":"Hao","sequence":"additional","affiliation":[{"name":"Department of Molecular Imaging School of Medical Technology Qiqihar Medical University  Qiqihar Heilongjiang P. R. 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