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While conventional PTT relies on photothermal agents (PTAs) to produce abundant heat (above 50\u00b0C) via near\u2010infrared (NIR) laser irradiation for tumor ablation, this high\u2010temperature approach often inflicts collateral thermal injury on surrounding healthy tissues, which severely constrains the therapeutic feasibility of PTT near vital organs. Therefore, mild\u2010temperature PTT (below 45\u00b0C) is of clinical interest. Herein, we construct an injectable hydrogel (IVH@gel) via the coordination between calcium ions (Ca\n                    <jats:sup>2<\/jats:sup>\n                    <jats:sup>+<\/jats:sup>\n                    ) and sodium alginate to encapsulate the PTA Hu Kaiwen Ink, the free radical initiator 2,2\u2019\u2010azobis[2\u2010(2\u2010imidazolin\u20102\u2010yl)propane]dihydrochloride (VA\u2010044), and the autophagy inhibitor hydroxychloroquine (HCQ) for realizing synergistic PTT and immunotherapy. Specifically, when irradiated under an NIR laser, the ink in the hydrogel generates heat, which leads to the degradation of VA\u2010044 to produce free radicals for killing cancer cells; meanwhile, HCQ is released for realizing autophagy\u2010inhibited mild\u2010temperature PTT of tumor. More importantly, the IVH@gel\u2010mediated PTT elicits strong immunogenic cell death (ICD), which activates a potent antitumor immune response, leading to significant tumor inhibition. This work provides a promising method for the development of multifunctional mild\u2010temperature PTT drugs.\n                  <\/jats:p>","DOI":"10.1002\/adhm.71619","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T06:14:37Z","timestamp":1788243277000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Triple\u2010Synergistic Injectable Hydrogel Elicits Systemic Antitumor Immunity via Mild Photothermal Priming, Radical Storm, and Autophagy Blockade"],"prefix":"10.1002","volume":"15","author":[{"given":"Yong\u2010Xi","family":"Zhou","sequence":"first","affiliation":[{"name":"State Key Laboratory of Digital Medical Engineering Jiangsu Key Laboratory for Biomaterials and Devices School of Biological Science and Medical Engineering Southeast University  Nanjing 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