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Although MN\u2010mediated delivery of curcumin and 5\u2010fluorouracil (5\u2010FU) has previously been reported using inkjet\/coating\u2010based approaches, those systems deposit drug formulations onto preformed solid MNs and are therefore constrained by surface coating uniformity, limited matrix integration, possible drug loss during handling, and less direct control over geometry\u2010dependent dose. Here, we report a distinct one\u2010step DLP 3D\u2010printing strategy in which hydrophilic 5\u2010FU and hydrophobic curcumin are incorporated directly into a single PEGDA\/VP photocurable resin before fabrication. The optimized resin enabled high\u2010resolution MN arrays with CAD\u2010defined dimensions, sharp tips, insertion efficiency above 95%, high drug entrapment, and controlled\/biphasic release behavior. Importantly, the work demonstrates that curcumin's optical absorbance can be managed through exposure optimization without compromising print fidelity, allowing dual\u2010drug\u2010loaded dissolving MNs to be manufactured directly from the therapeutic resin. These findings establish the system as a formulation\u2010process\u2010performance platform rather than a first report of curcumin\/5\u2010FU MN co\u2010delivery, providing a scalable and customizable approach for localized skin\u2010cancer drug delivery that warrants future biological validation.<\/jats:p>","DOI":"10.1002\/adhm.71620","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T12:33:26Z","timestamp":1787229206000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Biphasic Co\u2010Delivery of Curcumin and 5\u2010FU using 3D\u2010Printed Dissolving Microneedles for Skin Cancer Therapy"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-8255-5385","authenticated-orcid":false,"given":"Rutuja N.","family":"Meshram","sequence":"first","affiliation":[{"name":"School of Pharmacy Queen's University Belfast  Belfast UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8740-1661","authenticated-orcid":false,"given":"Dimitrios A.","family":"Lamprou","sequence":"additional","affiliation":[{"name":"School of Pharmacy Queen's University Belfast  Belfast UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,20]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2023.126697"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/CM9.0000000000003416"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.1980.tb00826.x"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbon.2025.119986"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2024.139956"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2024.12.079"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15112577"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym14081608"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15122767"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2025.1590534"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1088\/1758-5090\/ab6d37"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13346-024-01567-0"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/mi15121433"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2020.10.021"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2023.122647"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/jpp\/rgae043"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12272-017-0979-x"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.30688"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.7150\/jca.41783"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2021.153547"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-2918(01)80078-3"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2015.01.038"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.202400537"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2024.02.023"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2024.101090"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics17111498"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1116\/1.5095886"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2009.08.055"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-38838-2"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addma.2020.101736"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13346-023-01391-y"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-17841-5"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10973-010-1061-9"},{"key":"e_1_2_11_35_1","first-page":"410","article-title":"5th International Conference on Recent Advances in Materials, Minerals and Environment (Ramm) & 2nd International Postgraduate Conference on Materials","volume":"19","author":"Hamid Z. 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