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However, overcoming the poor competitiveness of glucose\u2010analog ligands to bind glucose molecules is highly challenging. In this study, parishins isolated from\n                    <jats:italic>Gastrodia elata<\/jats:italic>\n                    are reported as high\u2010affinity GLUT1 ligands(\u20109.859\u00a0kcal\/mol for parishin A), identifying them as novel class of high\u2010potential GLUT1 ligands. Using\n                    <jats:italic>G. elata<\/jats:italic>\n                    extract, parishin\u2010modified selenium nanoparticles (P@Se NPs) in a green one\u2010pot process were prepared. P@Se NPs perform uniform size and well\u2010defined core\u2010shell structure, where the Se NP core was coated with\n                    <jats:italic>G. elata<\/jats:italic>\n                    extract (hydrodynamic diameter: 92.73\u00b10.40\u00a0nm; zeta potential: \u221224.30\u00b10.55\u00a0mV). In a liver injury model, P@Se NPs shows enhanced GLUT1\u2010mediated uptake (4.03\u2010fold higher than that in free dye) and liver targeting (1.34\u2010fold higher than that in free dye). P@Se NPs effectively alleviated hepatocyte necrosis induced by mitochondrial dysfunction and significantly improved key liver function indicators (AST, ALT, LDH, and T\u2010Bil). Mechanistically, P@Se NPs restore mitochondrial function by normalizing oxidative stress (MDA, CAT, and SOD) and anti\u2010inflammation (iNOS, IL\u20101\u03b2, and TNF\u2010\u03b1), demonstrating effective GLUT1\u2010targeting\u2010assisted synergistic antioxidant and anti\u2010inflammatory effects for hepatoprotection. This study provides a novel biomimetic GLUT1\u2010targeted nanoplatform and offers a modern approach to developing traditional medicine components.\n                  <\/jats:p>","DOI":"10.1002\/adhm.71622","type":"journal-article","created":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T05:46:00Z","timestamp":1787377560000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["GLUT1\u2010Targeted Biomimetic Parishin\u2010Modified Nanoselenium for Organ Protection by Reestablishing Mitochondrial Homeostasis via Anti\u2010inflammatory and Antioxidant Pathways"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7400-1995","authenticated-orcid":false,"given":"Peng","family":"Tang","sequence":"first","affiliation":[{"name":"Yunnan Key Laboratory of Gastrodia and Fungi Symbiotic Biology College of Agronomy and Life Sciences Zhaotong University  Zhaotong Yunnan 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