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However, existing optical oximetry approaches typically assume stable blood volume, limiting their usefulness in real\u2010world scenarios involving vasoconstriction, vasodilation, or acute blood loss. Here, we leverage miniaturized optical sensors and Bluetooth microprocessors to create a fully implantable oximeter that measures subdermal tissue oxygenation and accounts for varying levels of blood volume. The device utilizes a wireless radiofrequency (RF) power transfer scheme that allows high bandwidth Bluetooth data transmission from three wavelength channels: green (537\u00a0nm), red (660\u00a0nm), and near\u2010infrared (NIR) (880\u00a0nm). Results show that the addition of a green wavelength improves tissue oxygenation estimation in the presence of varying blood volumes. In silico and in vivo validation of the device and tissue oxygenation algorithm is performed in rats during hypoxia, hypercapnia, and occlusion on a variety of tissues such as paw, subdermal muscle, and kidney. Miniaturized, wireless, battery\u2010free, implantable devices such as these that support mechanisms to compensate for varying blood volumes for StO\n                    <jats:sub>2<\/jats:sub>\n                    calculations offer the potential for continuous, real\u2010time, physiologically consistent monitoring of blood hemodynamics under dynamic physiological conditions.\n                  <\/jats:p>","DOI":"10.1002\/adhm.71623","type":"journal-article","created":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T04:41:16Z","timestamp":1787546476000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Multiwavelength Implantable Oximeter for Wireless Monitoring of Tissue Oxygenation in the Presence of Blood Volume Changes"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-4816-3486","authenticated-orcid":false,"given":"Anat","family":"Usatinsky","sequence":"first","affiliation":[{"name":"Institute of Biomedical Engineering University of Toronto  Toronto Ontario Canada"},{"name":"Ted Rogers Centre for Heart Research Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6733-4628","authenticated-orcid":false,"given":"Hugo L.","family":"Higueros\u2010Garcia","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Engineering University of Toronto  Toronto Ontario Canada"},{"name":"Ted Rogers Centre for Heart Research Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3557-8756","authenticated-orcid":false,"given":"Sadi","family":"Loai","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Engineering University of Toronto  Toronto Ontario Canada"},{"name":"Ted Rogers Centre for Heart Research Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2944-2005","authenticated-orcid":false,"given":"Samantha","family":"Unger","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Engineering University of Toronto  Toronto Ontario Canada"},{"name":"Ted Rogers Centre for Heart Research Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1627-5178","authenticated-orcid":false,"given":"Jacob","family":"Trueb","sequence":"additional","affiliation":[{"name":"Querry\u2010Simpson Institute of Bioelectronics Northwestern University  Evanston Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonatan","family":"Usatinsky","sequence":"additional","affiliation":[{"name":"Faculty of Science and Technology Athabasca University  Athabasca Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1329-7104","authenticated-orcid":false,"given":"Rawad","family":"Alkallas\u2010Valdiviezo","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Engineering University of Toronto  Toronto Ontario Canada"},{"name":"Ted Rogers Centre for Heart Research Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9351-446X","authenticated-orcid":false,"given":"Noor","family":"Abu Jarad","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Engineering University of Toronto  Toronto Ontario Canada"},{"name":"Ted Rogers Centre for Heart Research Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4786-786X","authenticated-orcid":false,"given":"Jonathan","family":"Wu","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Engineering University of Toronto  Toronto Ontario Canada"},{"name":"Ted Rogers Centre for Heart Research Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0733-9512","authenticated-orcid":false,"given":"Hai\u2010Ling M.","family":"Cheng","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Engineering University of Toronto  Toronto Ontario Canada"},{"name":"Ted Rogers Centre for Heart Research Toronto Ontario Canada"},{"name":"The Edward S. 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