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Here, we developed an injectable dual\u2010photocrosslinking microsphere (DP\u2010MS) bioink composed of Ru\/SPS, o\u2010nitrobenzyl\u2010modified hyaluronic acid (HANB), and gelatin methacryloyl (GelMA). Orthogonal green (525\u00a0nm) and UV (365\u00a0nm) light enable sequential crosslinking: first to generate cell\u2010laden microspheres, and the second step requires only 10 s to induce inter\u2010microsphere imine bonding without external adhesives. The dual\u2010photocrosslinking strategy preserved inter\u2010microsphere spaces,\u00a0facilitated rapid vascular ingrowth, and enhanced cell survival. In a subcutaneous implantation model, vascular volume in the DP\u2010MS group was approximately 7\u2010fold greater than that of constructs lacking inter\u2010microsphere voids; furthermore, encapsulated stem cells maintained persistent viability over 14 days. Importantly, this superior performance translated into significantly accelerated bone regeneration in a rat mandibular defect model. This platform thus provides a versatile and scalable strategy for developing cellularized products with clinical translation potential.<\/jats:p>","DOI":"10.1002\/adhm.71624","type":"journal-article","created":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T07:26:02Z","timestamp":1787815562000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Injectable Modular Cellularized Blocks via Dual\u2010Photocrosslinking for Enhanced Cell Therapy"],"prefix":"10.1002","volume":"15","author":[{"given":"Jiajia","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Prosthodontics Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine College of Stomatology, Shanghai Jiao Tong University National Center for Stomatology National Clinical Research Center for Oral Diseases Shanghai Key Laboratory of Stomatology Shanghai Research Institute of Stomatology  Shanghai 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