{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T23:16:13Z","timestamp":1789168573504,"version":"build-2803163510"},"reference-count":168,"publisher":"Wiley","issue":"34","license":[{"start":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T00:00:00Z","timestamp":1787270400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T00:00:00Z","timestamp":1787270400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002915","name":"Fondation pour la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The skin provides a model for regenerative medicine, prompting the design of cultured reconstructed tissue substitutes. Translational research and bioengineering have indeed given rise to clinical applications such as the grafting of cultured skin substitutes in severe burn patients, more than four decades ago, and more recently the correction of a genodermatosis by a cell and gene therapy approach. In addition, therapeutic uses of bioengineered skin substitutes are considered for chronic wounds and ulcers, which affect much larger patient populations. This history has given rise to multiple innovations involving original concepts, combined with new methodological and technical approaches. The variables relate to the cell sources used, which may include cells from neonatal or adult skin, autologous or allogeneic, or skin cells obtained by directed differentiation of pluripotent stem cells. They also concern methods and culture protocols used for cell expansion phase in two\u2010dimensional (2D) culture, then the production phase of 3D skin substitutes, a major current challenge being the elimination of constituents not chemically defined and\/or of animal origin. By outlining the main technological options, this review aims to guide the design of next\u2010generation skin substitutes that will reconcile biological performance, regulatory expectations and realistic clinical implementation.<\/jats:p>","DOI":"10.1002\/adhm.71630","type":"journal-article","created":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T05:41:08Z","timestamp":1787377268000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cellularized Skin Substitute Bioengineering for Regenerative Medicine: Cell Sources, Culture Strategies, and Transition Toward Defined, Xeno\u2010Free Culture Systems"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0898-1582","authenticated-orcid":false,"given":"Gilles","family":"Lema\u00eetre","sequence":"first","affiliation":[{"name":"CEA Laboratoire de R\u00e9g\u00e9n\u00e9ration et Radiopathologies Cutan\u00e9es (LR2C)  Evry France"},{"name":"CEA Institut de Biologie Fran\u00e7ois Jacob (IBFJ) D\u00e9partement de Radiobiologie Cellulaire et Mol\u00e9culaire (DRCM)  France"},{"name":"INSERM UMR Stabilit\u00e9 G\u00e9n\u00e9tique Cellules Souches et Radiations  France"},{"name":"Universit\u00e9 Evry Paris\u2010Saclay  France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9196-6588","authenticated-orcid":false,"given":"Marina","family":"Trouillas","sequence":"additional","affiliation":[{"name":"Centre de Transfusion Sanguine des Arm\u00e9es H\u00f4pital Percy  Clamart France"},{"name":"Inserm  Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0189-0573","authenticated-orcid":false,"given":"Tatiana","family":"Vinasco\u2010Sandoval","sequence":"additional","affiliation":[{"name":"CEA Laboratoire de R\u00e9g\u00e9n\u00e9ration et Radiopathologies Cutan\u00e9es (LR2C)  Evry France"},{"name":"CEA Institut de Biologie Fran\u00e7ois Jacob (IBFJ) D\u00e9partement de Radiobiologie Cellulaire et Mol\u00e9culaire (DRCM)  France"},{"name":"INSERM UMR Stabilit\u00e9 G\u00e9n\u00e9tique Cellules Souches et Radiations  France"},{"name":"Universit\u00e9 Paris\u2010Saclay  France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3641-8647","authenticated-orcid":false,"given":"C\u00e9cile","family":"Giordano","sequence":"additional","affiliation":[{"name":"CEA Laboratoire de R\u00e9g\u00e9n\u00e9ration et Radiopathologies Cutan\u00e9es (LR2C)  Evry France"},{"name":"CEA Institut de Biologie Fran\u00e7ois Jacob (IBFJ) D\u00e9partement de Radiobiologie Cellulaire et Mol\u00e9culaire (DRCM)  France"},{"name":"INSERM UMR Stabilit\u00e9 G\u00e9n\u00e9tique Cellules Souches et Radiations  France"},{"name":"Universit\u00e9 Paris\u2010Saclay  France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8191-8662","authenticated-orcid":false,"given":"Alexandre G.","family":"Lellouch","sequence":"additional","affiliation":[{"name":"Division of Plastic and Reconstructive Surgery Cedars\u2010Sinai Medical Center  Los Angeles California USA"},{"name":"H\u00f4pital Europ\u00e9en Georges Pompidou (HEGP) Innovative Therapies in Hemostasis Universit\u00e9 de Paris  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0829-7799","authenticated-orcid":false,"given":"Walid","family":"Rachidi","sequence":"additional","affiliation":[{"name":"CEA Inserm IRIG UA13 BGE\u2010Biomics and BGE\u2010 EDyP Universit\u00e9 Grenoble Alpes  Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Jacques","family":"Lataillade","sequence":"additional","affiliation":[{"name":"Centre de Transfusion Sanguine des Arm\u00e9es H\u00f4pital Percy  Clamart France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8702-247X","authenticated-orcid":false,"given":"Nicolas O.","family":"Fortunel","sequence":"additional","affiliation":[{"name":"CEA Laboratoire de R\u00e9g\u00e9n\u00e9ration et Radiopathologies Cutan\u00e9es (LR2C)  Evry France"},{"name":"CEA Institut de Biologie Fran\u00e7ois Jacob (IBFJ) D\u00e9partement de Radiobiologie Cellulaire et Mol\u00e9culaire (DRCM)  France"},{"name":"INSERM UMR Stabilit\u00e9 G\u00e9n\u00e9tique Cellules Souches et Radiations  France"},{"name":"Universit\u00e9 Paris\u2010Saclay  France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,21]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198408163110706"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature24487"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/bioengineering8050062"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/537433a"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40643\u2010015\u20100063\u20107"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2015.10.065"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioadv.2023.213428"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25073702"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2023.1154567"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2025.0609"},{"key":"e_1_2_12_12_1","unstructured":"D.Snyder N.Sullivan D.Margolis andK.Schoelles \u201cSkin Substitutes for Treating Chronic Wounds; AHRQ Technology Assessments; Agency for Healthcare Research and Quality (US) Rockville (MD) \u201d (2020)."},{"key":"e_1_2_12_13_1","doi-asserted-by":"crossref","unstructured":"F.Haxho Y.Lytvyn A. J.Shelley A.Ortega M.Melin andA.Alavi \u201cWound Care\u2014Part II: Tissue\u2010Engineered Skin Substitutes & Other Advanced Wound Therapies \u201dJournal of the American Academy of Dermatology(2025) https:\/\/doi.org\/10.1016\/j.jaad.2025.06.045 S0190962225023758.","DOI":"10.1016\/j.jaad.2025.06.045"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.137633"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2009.07.011"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2009.10.018"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/jbcr\/irad024"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/burnst\/tkad015"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2016.09.005"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/BCR.0B013E318031A236"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtv.2018.11.001"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2023.05.016"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472\u20106963\u20109\u2010115"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287\u2010019\u20101312\u2010z"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967\u2010024\u201005600\u20101"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40779\u2010023\u201000475\u20107"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/bioengineering8110148"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0305\u20104179(99)00143\u20106"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.2217\/17460751.2.6.887"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2011.03.001"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/BCR.0000000000000401"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12082"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.3390\/jfb6030547"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.CC.17.00250"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2025.103665"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000005746"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/jbcr\/irae150"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.14952"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2011.23.S3.S393"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.2147\/ciia.2007.2.1.93"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0305\u20104179(03)00164\u20105"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2024.05.023"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/0142\u20109612(91)90207\u2010Q"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004630\u2010199701000\u201000009"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/bies.20797"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2014.05.019"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/jbcr\/iry061"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2021.705019"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2019.08.014"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2010.10.005"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/btm2.10572"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200012150-00009"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1177\/0963689720973642"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1093\/jbcr\/irag014"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1089\/biores.2016.0036"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-59745-060-7_15"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.22203\/eCM.v036a10"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2108544"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.3389\/fsurg.2021.640879"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02344784"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2017.11.079"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2012.00809.x"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287\u2010026\u201004997\u20104"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reth.2022.09.009"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287\u2010024\u201003810\u20104"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201049400\u2010z"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065\u20102776(03)81006\u20104"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.772516"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.786859"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.8.2302"},{"key":"e_1_2_12_71_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100625.2009.01046.x"},{"key":"e_1_2_12_72_1","doi-asserted-by":"publisher","DOI":"10.1159\/000225956"},{"key":"e_1_2_12_73_1","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2014.187"},{"key":"e_1_2_12_74_1","first-page":"155","volume-title":"In Epidermal Cells Methods in Molecular Biology","author":"Fortunel N. O.","year":"2019"},{"key":"e_1_2_12_75_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells9102188"},{"key":"e_1_2_12_76_1","first-page":"101","volume-title":"Methods in Cell Biology","author":"Enzo E.","year":"2022"},{"key":"e_1_2_12_77_1","doi-asserted-by":"publisher","DOI":"10.2217\/rme.13.43"},{"key":"e_1_2_12_78_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199909270-00021"},{"key":"e_1_2_12_79_1","doi-asserted-by":"publisher","DOI":"10.5966\/sctm.2014\u20100155"},{"key":"e_1_2_12_80_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.17.2.299"},{"key":"e_1_2_12_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092\u20108674(75)80001\u20108"},{"key":"e_1_2_12_82_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.81.24.7802"},{"key":"e_1_2_12_83_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1253734"},{"key":"e_1_2_12_84_1","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S83676"},{"key":"e_1_2_12_85_1","doi-asserted-by":"publisher","DOI":"10.3233\/BME\u20102009\u20100601"},{"key":"e_1_2_12_86_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms14034684"},{"key":"e_1_2_12_87_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.2006.12.245"},{"key":"e_1_2_12_88_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1067\u20101927.2004.12609.x"},{"key":"e_1_2_12_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2024.06.011"},{"key":"e_1_2_12_90_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11071151"},{"key":"e_1_2_12_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(09)61496\u20103"},{"key":"e_1_2_12_92_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1100332108"},{"key":"e_1_2_12_93_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0077673"},{"key":"e_1_2_12_94_1","doi-asserted-by":"publisher","DOI":"10.1186\/scrt51"},{"key":"e_1_2_12_95_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2014.102"},{"key":"e_1_2_12_96_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1019070108"},{"key":"e_1_2_12_97_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24076398"},{"key":"e_1_2_12_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scr.2020.102035"},{"key":"e_1_2_12_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scr.2021.102451"},{"key":"e_1_2_12_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2009.12.002"},{"key":"e_1_2_12_101_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383\u2010014\u20103622\u20107"},{"key":"e_1_2_12_102_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12570"},{"key":"e_1_2_12_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellbi.2007.03.009"},{"key":"e_1_2_12_104_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcmr.12609"},{"key":"e_1_2_12_105_1","doi-asserted-by":"publisher","DOI":"10.1002\/term.2959"},{"key":"e_1_2_12_106_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2003.69"},{"key":"e_1_2_12_107_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20106143.2005.00790.x"},{"key":"e_1_2_12_108_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383\u2010015\u20103808\u20107"},{"key":"e_1_2_12_109_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287\u2010024\u201003901\u20102"},{"key":"e_1_2_12_110_1","doi-asserted-by":"publisher","DOI":"10.1093\/burnst\/tkaf006"},{"key":"e_1_2_12_111_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202201626"},{"key":"e_1_2_12_112_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010018\u201007579\u2010y"},{"key":"e_1_2_12_113_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10735\u2010018\u20109773\u20104"},{"key":"e_1_2_12_114_1","doi-asserted-by":"crossref","unstructured":"B.Magne B.Cattier M.Lemire\u2010Rondeau et\u00a0al. \u201cDe Novo Formation of human Sebaceous Glands Using Self\u2010assembled Skin Substitutes \u201dJournal of Investigative Dermatology146(2026) https:\/\/doi.org\/10.1016\/j.jid.2026.03.021 S0022202X26010109.","DOI":"10.1016\/j.jid.2026.03.021"},{"key":"e_1_2_12_115_1","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.13217"},{"key":"e_1_2_12_116_1","doi-asserted-by":"publisher","DOI":"10.3390\/ebj6020030"},{"key":"e_1_2_12_117_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41409\u2010023\u201001962\u20100"},{"key":"e_1_2_12_118_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102133.2006.07266.x"},{"key":"e_1_2_12_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2023.06.045"},{"key":"e_1_2_12_120_1","doi-asserted-by":"publisher","DOI":"10.1007\/7651_2024_551"},{"key":"e_1_2_12_121_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403\u2010017\u20101774\u20108"},{"key":"e_1_2_12_122_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000637-198503000-00011"},{"key":"e_1_2_12_123_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02634257"},{"key":"e_1_2_12_124_1","doi-asserted-by":"publisher","DOI":"10.1177\/0963689719833305"},{"key":"e_1_2_12_125_1","doi-asserted-by":"publisher","DOI":"10.1016\/0305\u20104179(93)90028\u20107"},{"key":"e_1_2_12_126_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reth.2021.09.005"},{"key":"e_1_2_12_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092\u20108674(85)90216\u20108"},{"key":"e_1_2_12_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092\u20108674(94)90383\u20102"},{"key":"e_1_2_12_129_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241612537"},{"key":"e_1_2_12_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2006.11.002"},{"key":"e_1_2_12_131_1","doi-asserted-by":"publisher","DOI":"10.1002\/bit.260430809"},{"key":"e_1_2_12_132_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005373\u2010198807000\u201000023"},{"key":"e_1_2_12_133_1","doi-asserted-by":"publisher","DOI":"10.1177\/026119290203000208"},{"key":"e_1_2_12_134_1","doi-asserted-by":"publisher","DOI":"10.1159\/000534137"},{"key":"e_1_2_12_135_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523\u20101747.ep12540422"},{"key":"e_1_2_12_136_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1041210106"},{"key":"e_1_2_12_137_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xjidi.2024.100298"},{"key":"e_1_2_12_138_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10561-011-9247-3"},{"key":"e_1_2_12_139_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11071130"},{"key":"e_1_2_12_140_1","doi-asserted-by":"publisher","DOI":"10.1186\/scrt449"},{"key":"e_1_2_12_141_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.09.072"},{"key":"e_1_2_12_142_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23126552"},{"key":"e_1_2_12_143_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441\u2010022\u201003698\u20107"},{"key":"e_1_2_12_144_1","article-title":"Production of Autologous Platelet\u2010Rich Plasma for Boosting in Vitro Human Fibroblast Expansion","volume":"168","author":"Berndt S.","year":"2021","journal-title":"JoVE"},{"key":"e_1_2_12_145_1","doi-asserted-by":"publisher","DOI":"10.1080\/09537104.2020.1856356"},{"key":"e_1_2_12_146_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0052494"},{"key":"e_1_2_12_147_1","doi-asserted-by":"publisher","DOI":"10.1159\/000362927"},{"key":"e_1_2_12_148_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199512000-00008"},{"key":"e_1_2_12_149_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24031821"},{"key":"e_1_2_12_150_1","doi-asserted-by":"publisher","DOI":"10.1002\/btm2.10324"},{"key":"e_1_2_12_151_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02634047"},{"key":"e_1_2_12_152_1","doi-asserted-by":"publisher","DOI":"10.1016\/0305-4179(89)90007-7"},{"key":"e_1_2_12_153_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365\u20102133.1998.02364.x"},{"key":"e_1_2_12_154_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reth.2017.03.002"},{"key":"e_1_2_12_155_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1992.01680150063007"},{"issue":"4","key":"e_1_2_12_156_1","first-page":"S73","article-title":"Use of Allogenic Epidermal Sheets for Difficult Wound Healing: Selection and Testing of Relevant Growth Factors","volume":"16","author":"Auxenfans C.","year":"2006","journal-title":"Biomed Mater Eng"},{"key":"e_1_2_12_157_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004410100450"},{"key":"e_1_2_12_158_1","doi-asserted-by":"publisher","DOI":"10.1093\/jbcr\/iraa191"},{"key":"e_1_2_12_159_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tec.2015.0258"},{"key":"e_1_2_12_160_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468\u20103083.2004.00873.x"},{"key":"e_1_2_12_161_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reth.2023.02.003"},{"key":"e_1_2_12_162_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010022\u201007156\u2010w"},{"key":"e_1_2_12_163_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2022.10.006"},{"key":"e_1_2_12_164_1","doi-asserted-by":"publisher","DOI":"10.1116\/6.0004978"},{"key":"e_1_2_12_165_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-38366-w"},{"key":"e_1_2_12_166_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsabm.3c01303"},{"key":"e_1_2_12_167_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41551\u2010019\u20100464\u20106"},{"key":"e_1_2_12_168_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2020.575146"},{"key":"e_1_2_12_169_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2017.09.018"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.71630","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adhm.71630","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.71630","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T22:40:39Z","timestamp":1789166439000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.71630"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,21]]},"references-count":168,"journal-issue":{"issue":"34","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/adhm.71630"],"URL":"https:\/\/doi.org\/10.1002\/adhm.71630","archive":["Portico"],"relation":{},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,21]]},"assertion":[{"value":"2026-03-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71630"}}