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Such microbial imbalance compromised intestinal barrier integrity, facilitating the translocation of enterogenous urinary toxins and opportunistic pathogens into the bloodstream. This process subsequently activated intestinal mucosal immunity, triggers systemic microinflammatory responses, and exacerbated kidney injury. Herein, we reported a biocompatible, carrier\u2010free nanomachine system based on tungsten trioxide (WO\n                    <jats:sub>3<\/jats:sub>\n                    ) for the active delivery of WO\n                    <jats:sub>3<\/jats:sub>\n                    to protect both the intestines and kidneys by preserving intestinal homeostasis via the gut\u2010kidney axis in vivo. Platinum (Pt) nanoparticles were asymmetrically deposited onto the surface of WO\n                    <jats:sub>3<\/jats:sub>\n                    to enable controlled O\n                    <jats:sub>2<\/jats:sub>\n                    release in response to the in vivo microenvironment. The locally generated O\n                    <jats:sub>2<\/jats:sub>\n                    not only acted synergistically with WO\n                    <jats:sub>3<\/jats:sub>\n                    to ameliorate intestinal and renal damage but also served as a propellant to drive nanomachine motion. Upon accumulation in intestinal tissues, the nanomachines exhibited reactive oxygen species (ROS)\u2010responsive autonomous movement, which enhanced WO\n                    <jats:sub>3<\/jats:sub>\n                    diffusion and promoted therapeutic efficacy. This targeted motion facilitated intestinal injury repair, restored intestinal homeostasis, and consequently improved renal function. Overall, this rationally designed nanomachine system represented a promising platform for the combined protection of intestinal and renal health through modulation of intestinal homeostasis.\n                  <\/jats:p>","DOI":"10.1002\/adhm.71639","type":"journal-article","created":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T05:28:51Z","timestamp":1787290131000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Self\u2010Propelling WO\n                    <sub>3<\/sub>\n                    Nanomotors Restore the Gut\u2010Kidney Axis by Modulating Intestinal Homeostasis in Inflammatory Bowel Disease"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-9011-5189","authenticated-orcid":false,"given":"Lin","family":"Zhang","sequence":"first","affiliation":[{"name":"Binzhou Medical University  Yantai P. R. 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3095-6911","authenticated-orcid":false,"given":"Xinling","family":"Li","sequence":"additional","affiliation":[{"name":"Georgia Institute of Technology and Emory University  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2717-8012","authenticated-orcid":false,"given":"Guanghui","family":"Xiao","sequence":"additional","affiliation":[{"name":"Mississippi State University  Mississippi State MS USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7765-8906","authenticated-orcid":false,"given":"Senlin","family":"Liu","sequence":"additional","affiliation":[{"name":"Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingli","family":"Xue","sequence":"additional","affiliation":[{"name":"Xi'an Medical University  Xi'an P. R. 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