{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T10:52:19Z","timestamp":1791543139804,"version":"4.3.4"},"reference-count":145,"publisher":"Wiley","issue":"37","license":[{"start":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T00:00:00Z","timestamp":1787529600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T00:00:00Z","timestamp":1787529600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR\u201022\u2010CPJ1\u20100077\u201001"],"award-info":[{"award-number":["ANR\u201022\u2010CPJ1\u20100077\u201001"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Silicone breast implants have long been associated with the gradual release of low molecular weight siloxanes from the inner gel through the implant membrane into the periprosthetic biological environment, a phenomenon commonly referred to as \u201cgel bleed.\u201d Despite more than five decades of investigation spanning polymer science, transport theory, and biomedical research, the physicochemical mechanisms underlying silicone permeation remain conceptually fragmented. Here, we revisit silicone permeation by examining how molecular transport arises from the intrinsic interplay between polymer architecture, thermodynamic partitioning, and diffusional mobility within crosslinked networks. We further analyze the key determinants of permeation, including implant aging, barrier\u2010layer technologies, and interaction with the periprosthetic tissue environment. We further discuss how dynamic bio\u2010interfaces influence bidirectional transport and bioaccumulation in vivo. Beyond their implications for implant performance, these observations provide broader conceptual insights into mass transport in soft materials, highlighting general principles relevant to elastomers, hydrogels, and drug\u2010delivery systems. By integrating material structure, transport physics and host interactions, this review establishes a mechanistic viewpoint on polymer permeation in vivo and offers design considerations for next\u2010generation soft implantable biomaterials.<\/jats:p>","DOI":"10.1002\/adhm.71641","type":"journal-article","created":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T10:40:48Z","timestamp":1787568048000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Silicone Breast Implants as a Model System for Understanding Polymer Permeation in Soft Materials In Vivo"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8442-1501","authenticated-orcid":false,"given":"D.","family":"Bouyer","sequence":"first","affiliation":[{"name":"Institut Europ\u00e9en des Membranes CNRS IEM Universit\u00e9 De Montpellier  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4683-0515","authenticated-orcid":false,"given":"H.","family":"Mutlu","sequence":"additional","affiliation":[{"name":"Department of Chemistry Technical Polymer Chemistry Rheinland\u2010Pf\u00e4lzische Technische Universit\u00e4t Kaiserslautern\u2010Landau (RPTU) Erwin\u2010Schr\u00f6dinger\u2010Stra\u00dfe  Kaiserslautern Germany"},{"name":"Institut de Science des Mat\u00e9riaux de Mulhouse UMR 7361 CNRS\/Universit\u00e9 De Haute Alsace  Mulhouse Cedex France"},{"name":"Laboratory of Organic and Macromolecular Chemistry (IOMC) Friedrich Schiller University Jena  Humboldtstr. 10 Germany"},{"name":"Helmholtz Institute for Polymers in Energy Applications Jena (HIPOLE Jena)  Jena Germany"},{"name":"Helmholtz\u2010Zentrum Berlin for Materials and Energy GmbH  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2352-9823","authenticated-orcid":false,"given":"C.","family":"Charmette","sequence":"additional","affiliation":[{"name":"Institut Europ\u00e9en des Membranes CNRS IEM Universit\u00e9 De Montpellier  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7613-4121","authenticated-orcid":false,"given":"E.","family":"Randrianaridera","sequence":"additional","affiliation":[{"name":"Institut de Science des Mat\u00e9riaux de Mulhouse UMR 7361 CNRS\/Universit\u00e9 De Haute Alsace  Mulhouse Cedex France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Adaidi","sequence":"additional","affiliation":[{"name":"Institut Europ\u00e9en des Membranes CNRS IEM Universit\u00e9 De Montpellier  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6840-9169","authenticated-orcid":false,"given":"R.","family":"Hedna","sequence":"additional","affiliation":[{"name":"Institut de Science des Mat\u00e9riaux de Mulhouse UMR 7361 CNRS\/Universit\u00e9 De Haute Alsace  Mulhouse Cedex France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3408-0662","authenticated-orcid":false,"given":"L.","family":"Pieuchot","sequence":"additional","affiliation":[{"name":"Institut de Science des Mat\u00e9riaux de Mulhouse UMR 7361 CNRS\/Universit\u00e9 De Haute Alsace  Mulhouse Cedex France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Pluvy","sequence":"additional","affiliation":[{"name":"CHU Besan\u00e7on Laboratoire SINERGIES Service D'orthop\u00e9die Traumatologie et Chirurgie Plastique Universit\u00e9 De Franche\u2010Comt\u00e9  Besan\u00e7on France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6669-205X","authenticated-orcid":false,"given":"K.","family":"Anselme","sequence":"additional","affiliation":[{"name":"Institut de Science des Mat\u00e9riaux de Mulhouse UMR 7361 CNRS\/Universit\u00e9 De Haute Alsace  Mulhouse Cedex France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9150-8034","authenticated-orcid":false,"given":"N.","family":"Couturier","sequence":"additional","affiliation":[{"name":"Institut de Science des Mat\u00e9riaux de Mulhouse UMR 7361 CNRS\/Universit\u00e9 De Haute Alsace  Mulhouse Cedex France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4134-8930","authenticated-orcid":false,"given":"J. P.","family":"Mericq","sequence":"additional","affiliation":[{"name":"Institut Europ\u00e9en des Membranes CNRS IEM Universit\u00e9 De Montpellier  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8993-2896","authenticated-orcid":false,"given":"A.","family":"Ponche","sequence":"additional","affiliation":[{"name":"Institut de Science des Mat\u00e9riaux de Mulhouse UMR 7361 CNRS\/Universit\u00e9 De Haute Alsace  Mulhouse Cedex France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8176-791X","authenticated-orcid":false,"given":"I.","family":"Brigaud","sequence":"additional","affiliation":[{"name":"Institut de Science des Mat\u00e9riaux de Mulhouse UMR 7361 CNRS\/Universit\u00e9 De Haute Alsace  Mulhouse Cedex France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,24]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1308\/rcsann.2020.0003"},{"key":"e_1_2_14_3_1","unstructured":"ISAPS International Survey on (accessed February 12 2025) www.isaps.org."},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/bioengineering12121307"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-814213-4.00007-1"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1533\/9780857096418.52"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1039\/D4PY01051E"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0141\u20103910(01)00261\u20100"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-197861060-00002"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01570272"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anplas.2025.02.006"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0049\u20100172(94)90104\u2010X"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.23937\/2378\u20103656\/1410087"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/asj\/sjab051"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/2292550317716127"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotri.2020.100133"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/S00266\u2010023\u201003329\u20108\/METRICS"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00266\u2010019\u201001521\u20103"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.SMIM.2007.11.004"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ADMA.202205709"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2024.123025"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.37871\/JBRES1745"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.7759\/CUREUS.101747"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/ASJ\/SJAD086"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/GOX.0000000000006458"},{"key":"e_1_2_14_26_1","unstructured":"Saline Silicone Gel and Alternative Breast Implants Guidance for Industry and Food and Drug Administration Staff Preface Public Comment (accessed October 24 2025) https:\/\/www.regulations.gov."},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.1080\/1744666X.2022.2010546"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.AUTREV.2023.103448"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.5999\/aps.2020.02117"},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.21037\/gs\u201021\u2010135"},{"key":"e_1_2_14_31_1","doi-asserted-by":"publisher","DOI":"10.21037\/GS\u201020\u2010231"},{"key":"e_1_2_14_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpra.2022.02.004"},{"key":"e_1_2_14_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000000348"},{"key":"e_1_2_14_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534\u2010197208000\u201000001"},{"key":"e_1_2_14_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534\u2010198402000\u201000022"},{"key":"e_1_2_14_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534\u2010198502000\u201000027"},{"key":"e_1_2_14_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534\u2010197710000\u201000020"},{"key":"e_1_2_14_38_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100039\u20101696985"},{"key":"e_1_2_14_39_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1988.03410020102037"},{"key":"e_1_2_14_40_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejm199506223322502"},{"key":"e_1_2_14_41_1","doi-asserted-by":"publisher","DOI":"10.21037\/GS\u201021\u2010266"},{"key":"e_1_2_14_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2013.568"},{"key":"e_1_2_14_43_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534\u2010199710000\u201000035"},{"key":"e_1_2_14_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/JBM.820231406"},{"key":"e_1_2_14_45_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000637\u2010199211000\u201000009"},{"key":"e_1_2_14_46_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000004284"},{"key":"e_1_2_14_47_1","doi-asserted-by":"publisher","DOI":"10.1055\/S\u20100031\u20101298323"},{"key":"e_1_2_14_48_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534\u2010199708000\u201000065"},{"key":"e_1_2_14_49_1","unstructured":"Update on the Safety of Silicone Gel\u2010Filled Breast Implants (2011)\u2014Executive Summary | FDA (n.d.) (accessed February 5 2025) https:\/\/www.fda.gov\/medical\u2010devices\/breast\u2010implants\/update\u2010safety\u2010silicone\u2010gel\u2010filled\u2010breast\u2010implants\u20102011\u2010executive\u2010summary."},{"key":"e_1_2_14_50_1","doi-asserted-by":"publisher","DOI":"10.1182\/BLOOD\u20102016\u201001\u2010643569"},{"key":"e_1_2_14_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JPRA.2021.11.006"},{"key":"e_1_2_14_52_1","unstructured":"UPDATE: Reports of Squamous Cell Carcinoma (SCC) in the Capsule Around Breast Implants\u2014FDA Safety Communication | FDA (n.d.) (accessed March 7 2025) https:\/\/www.fda.gov\/medical\u2010devices\/safety\u2010communications\/update\u2010reports\u2010squamous\u2010cell\u2010carcinoma\u2010scc\u2010capsule\u2010around\u2010breast\u2010implants\u2010fda\u2010safety\u2010communication."},{"key":"e_1_2_14_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmbbm.2011.06.019"},{"key":"e_1_2_14_54_1","doi-asserted-by":"publisher","DOI":"10.1163\/156856202753525918"},{"key":"e_1_2_14_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmbbm.2017.04.005"},{"key":"e_1_2_14_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.CPS.2020.09.006"},{"key":"e_1_2_14_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JPBA.2014.09.008"},{"key":"e_1_2_14_58_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00266\u2010010\u20109483\u20100"},{"key":"e_1_2_14_59_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00216\u2010004\u20102714\u2010y"},{"key":"e_1_2_14_60_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524\u20104741.2003.09518.x"},{"key":"e_1_2_14_61_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01577858"},{"key":"e_1_2_14_62_1","doi-asserted-by":"publisher","DOI":"10.1093\/asj\/sjad363"},{"key":"e_1_2_14_63_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.51.7.493"},{"key":"e_1_2_14_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2018.03.041"},{"key":"e_1_2_14_65_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000011395"},{"key":"e_1_2_14_66_1","article-title":"A 10\u2010Year Prospective Study of Implant\u2010Based Breast Augmentation and Reconstruction","volume":"18","author":"El\u2010Haddad R.","year":"2018","journal-title":"Eplasty"},{"key":"e_1_2_14_67_1","doi-asserted-by":"crossref","unstructured":"J.Daenicke D. W.Schubert M.Hedenqvist E.Linde T.Sigl andR. E.Horch \u201cEvaluation of the Influence of Crosslink Density and Penetrant Size on the Diffusion Properties of Silicone Oils Into Silicone Elastomers \u201d inAIP Conf. Proc. (AIP Publishing LLC AIP Publishing 2019) 080004 https:\/\/doi.org\/10.1063\/1.5084878.","DOI":"10.1063\/1.5084878"},{"key":"e_1_2_14_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0376\u20107388(03)00024\u20103"},{"key":"e_1_2_14_69_1","doi-asserted-by":"publisher","DOI":"10.1021\/MA990685R"},{"key":"e_1_2_14_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978\u20100\u2010444\u201063776\u20105.00014\u20100"},{"key":"e_1_2_14_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.MEMSCI.2008.04.030"},{"key":"e_1_2_14_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/0376\u20107388(94)00060\u20103"},{"key":"e_1_2_14_73_1","doi-asserted-by":"publisher","DOI":"10.1163\/156856201750411675"},{"key":"e_1_2_14_74_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac970710w"},{"key":"e_1_2_14_75_1","doi-asserted-by":"publisher","DOI":"10.1021\/AC000738Z"},{"key":"e_1_2_14_76_1","doi-asserted-by":"publisher","DOI":"10.1007\/S00216\u2010002\u20101694\u2010Z"},{"key":"e_1_2_14_77_1","doi-asserted-by":"publisher","DOI":"10.1007\/S00216\u2010016\u20109401\u20107"},{"key":"e_1_2_14_78_1","doi-asserted-by":"publisher","DOI":"10.1021\/ma00073a018"},{"key":"e_1_2_14_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.memsci.2025.124731"},{"key":"e_1_2_14_80_1","doi-asserted-by":"publisher","DOI":"10.1002\/pol.1977.180150303"},{"key":"e_1_2_14_81_1","doi-asserted-by":"publisher","DOI":"10.1002\/AIC.690380309"},{"key":"e_1_2_14_82_1","doi-asserted-by":"publisher","DOI":"10.1093\/ASJ\/SJY103"},{"key":"e_1_2_14_83_1","first-page":"13","article-title":"Silicone Gel Bleed on Breast Implants","volume":"7","author":"Louren\u00e7o F. R.","year":"2011","journal-title":"Surgery"},{"key":"e_1_2_14_84_1","doi-asserted-by":"publisher","DOI":"10.1021\/ma00098a009"},{"key":"e_1_2_14_85_1","volume-title":"Diffusion in Polymers","author":"Crank J.","year":"2026"},{"key":"e_1_2_14_86_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0B013E318262F174"},{"key":"e_1_2_14_87_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.25381"},{"key":"e_1_2_14_88_1","volume-title":"Safety of Silicone Breast Implants","author":"Bondurant S.","year":"1999"},{"key":"e_1_2_14_89_1","doi-asserted-by":"publisher","DOI":"10.21037\/gs.2016.11.09"},{"key":"e_1_2_14_90_1","doi-asserted-by":"publisher","DOI":"10.1007\/S00238\u2010018\u20101427\u2010Y"},{"key":"e_1_2_14_91_1","doi-asserted-by":"publisher","DOI":"10.4414\/smw.2012.13614"},{"key":"e_1_2_14_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seppur.2016.11.065"},{"key":"e_1_2_14_93_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/5610282"},{"key":"e_1_2_14_94_1","doi-asserted-by":"publisher","DOI":"10.4414\/smw.2012.13614"},{"key":"e_1_2_14_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmbbm.2017.12.001"},{"key":"e_1_2_14_96_1","doi-asserted-by":"publisher","DOI":"10.1021\/la903445x"},{"key":"e_1_2_14_97_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10544\u2010013\u20109808\u20102"},{"key":"e_1_2_14_98_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10965\u2010012\u20109869\u20106"},{"key":"e_1_2_14_99_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym13183125"},{"key":"e_1_2_14_100_1","doi-asserted-by":"publisher","DOI":"10.1002\/JBM.820210602"},{"key":"e_1_2_14_101_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.820060504"},{"key":"e_1_2_14_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmbbm.2015.02.008"},{"key":"e_1_2_14_103_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534\u2010199801000\u201000011"},{"key":"e_1_2_14_104_1","doi-asserted-by":"publisher","DOI":"10.1093\/asj\/sjy018"},{"key":"e_1_2_14_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.polymer.2008.04.041"},{"key":"e_1_2_14_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmbbm.2018.10.042"},{"key":"e_1_2_14_107_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02789186"},{"key":"e_1_2_14_108_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/107.2.236"},{"key":"e_1_2_14_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0946\u2010672X(00)80021\u20108"},{"key":"e_1_2_14_110_1","doi-asserted-by":"publisher","DOI":"10.1366\/0003702934334750"},{"key":"e_1_2_14_111_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm0297\u2010235"},{"key":"e_1_2_14_112_1","doi-asserted-by":"publisher","DOI":"10.1002\/JBIO.201960197"},{"key":"e_1_2_14_113_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000010359"},{"key":"e_1_2_14_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anplas.2022.08.002"},{"key":"e_1_2_14_115_1","doi-asserted-by":"publisher","DOI":"10.1097\/GOX.0000000000005608"},{"key":"e_1_2_14_116_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbio.202400415"},{"key":"e_1_2_14_117_1","doi-asserted-by":"publisher","DOI":"10.1039\/c1ra00198a"},{"key":"e_1_2_14_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2024.01.006"},{"key":"e_1_2_14_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006\u20103495(95)80388\u20107"},{"key":"e_1_2_14_120_1","doi-asserted-by":"publisher","DOI":"10.1163\/156856203321142560"},{"key":"e_1_2_14_121_1","doi-asserted-by":"publisher","DOI":"10.1021\/BM040041D"},{"key":"e_1_2_14_122_1","doi-asserted-by":"publisher","DOI":"10.1002\/jps.24351"},{"key":"e_1_2_14_123_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2015.03.013"},{"key":"e_1_2_14_124_1","doi-asserted-by":"publisher","DOI":"10.3390\/IJMS22168460"},{"key":"e_1_2_14_125_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00266\u2010025\u201005142\u2010x"},{"key":"e_1_2_14_126_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgwh.2022.730276"},{"key":"e_1_2_14_127_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOL.0000000000000983"},{"key":"e_1_2_14_128_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.PAS.0000155145.60670.E4"},{"key":"e_1_2_14_129_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.CHEMOSPHERE.2016.04.094"},{"key":"e_1_2_14_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JHAZMAT.2025.140933"},{"key":"e_1_2_14_131_1","doi-asserted-by":"publisher","DOI":"10.1242\/JCS.1988.SUPPLEMENT_9.7"},{"key":"e_1_2_14_132_1","doi-asserted-by":"publisher","DOI":"10.1042\/BST0350454"},{"key":"e_1_2_14_133_1","doi-asserted-by":"publisher","DOI":"10.3390\/BIOMEDICINES9080915"},{"key":"e_1_2_14_134_1","doi-asserted-by":"publisher","DOI":"10.1093\/ASJ\/SJAE128"},{"key":"e_1_2_14_135_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICL.0000000000000052"},{"key":"e_1_2_14_136_1","doi-asserted-by":"publisher","DOI":"10.1167\/IOVS.10\u20105836"},{"key":"e_1_2_14_137_1","doi-asserted-by":"publisher","DOI":"10.1001\/JAMANETWORKOPEN.2021.28947"},{"key":"e_1_2_14_138_1","doi-asserted-by":"publisher","DOI":"10.1021\/ACSNANO.0C06319\/ASSET\/IMAGES\/LARGE\/NN0C06319_0004.JPEG"},{"key":"e_1_2_14_139_1","doi-asserted-by":"publisher","DOI":"10.1089\/JOP.2012.0212"},{"key":"e_1_2_14_140_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1542\u20100124(12)70262\u20108"},{"key":"e_1_2_14_141_1","doi-asserted-by":"publisher","DOI":"10.1097\/OPX.0000000000002267"},{"key":"e_1_2_14_142_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.EJPS.2025.107035"},{"key":"e_1_2_14_143_1","doi-asserted-by":"publisher","DOI":"10.3109\/03639049809085616"},{"key":"e_1_2_14_144_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.EJPS.2011.02.011"},{"key":"e_1_2_14_145_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010018\u201006851\u20105"},{"key":"e_1_2_14_146_1","doi-asserted-by":"publisher","DOI":"10.3390\/MOLECULES26185577"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.71641","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adhm.71641","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.71641","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T10:10:18Z","timestamp":1791540618000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.71641"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,24]]},"references-count":145,"journal-issue":{"issue":"37","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/adhm.71641"],"URL":"https:\/\/doi.org\/10.1002\/adhm.71641","archive":["Portico"],"relation":{},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,24]]},"assertion":[{"value":"2026-06-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71641"}}