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How to make a safe and efficient repair without disturbing surrounding tissues is critical, especially in external\u2010stimulus\u2010enhanced regeneration strategy. Magnetic hyperthermia therapy (MHT), due to its ability of uniform heat generation and good penetration, has gained increasing attention in bone repair. An asymmetric magnetic microspheres hybrid hydrogel was developed with magnetothermal responsiveness for targeted heating at the defect, preventing the risk of potential thermal injury to adjacent critical tissues. Guided by an external magnetic field, magnetic microspheres distributed in the upper side of the hydrogel achieved localized mild heating (40\u00b0C\u201342\u00b0C) under an alternating magnetic field (AMF), whereas the lower side remained within a physiologically safe temperature (&lt; 38\u00b0C). In vitro and in vivo experiments showed that the asymmetric magnetic hydrogel under safe magnetothermal stimulation significantly enhanced the osteogenic differentiation and vascularization. Furthermore, transcriptomic analysis and histological staining suggested that this platform may convert external magnetothermal stimulation into intracellular signals by activating the PI3K\u2010Akt pathway and upregulating key osteogenic and angiogenic markers. Overall, this asymmetric magnetothermal hydrogel offers a spatially controlled, safe, and effective strategy for bone regeneration.<\/jats:p>","DOI":"10.1002\/adhm.71642","type":"journal-article","created":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T04:44:27Z","timestamp":1787546667000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["An Asymmetric Magnetic Hydrogel With Mild Magnetothermal Effect for Safe and Efficient Bone Repair"],"prefix":"10.1002","volume":"15","author":[{"given":"Mengxian","family":"Chu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oral Diseases &amp; National Center For Stomatology &amp; National Clinical Research Center for Oral Diseases West China Hospital of Stomatology Sichuan University  Chengdu Sichuan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasmine 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