{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T05:00:50Z","timestamp":1790312450013,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"36","license":[{"start":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T00:00:00Z","timestamp":1787270400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T00:00:00Z","timestamp":1787270400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The development of organic photocatalysts holds considerable promise for the oxidation of NADH, thereby disrupting the NADH\/NAD+ equilibrium, modulating redox homeostasis, and enhancing treatment of hypoxic tumors. However, there is still a lack of organic photocatalyst which could respond to near\u2010infrared light. Herein, we develop an NIR\u2010triggered organic photocatalyst (TTH) that produces hydroxyl radical and photooxidates NADH. Upon 808\u00a0nm light irradiation, TTH not only could generate hydroxyl radical in an optimized pathway of O\n                    <jats:sub>2<\/jats:sub>\n                    \u2192O\n                    <jats:sub>2<\/jats:sub>\n                    <jats:sup>\u2022<\/jats:sup>\n                    <jats:bold>\n                      <jats:sup>\u2212<\/jats:sup>\n                    <\/jats:bold>\n                    \u2192H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    \u2192\u2022OH and achieve effective oxidation of NADH and the reduction of cytochrome c, but also produces hyperthermia, facilitating NIR\u2010II fluorescence\u2010guided phototherapy of tumors. Moreover, TTH preferentially degrades glutathione, increases lipid peroxide levels, and downregulates glutathione peroxidase 4, culminating in mitochondrial dysfunction and the initiation of ferroptosis\u2011like cell death. Subsequently, the in vivo experiments proved that the photocatalytic TTH achieved antitumor efficacy in 4T1\u2010bearing mouse models. Collectively, our research highlights the potential of employing an NIR\u2010activated organic photocatalyst to integrate phototherapy with hydroxyl radical generation, representing a promising therapeutic strategy to disrupt intracellular redox homeostasis for the treatment of tumors.\n                  <\/jats:p>","DOI":"10.1002\/adhm.71645","type":"journal-article","created":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T05:42:16Z","timestamp":1787377336000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["NIR\u2010Triggered Hydroxyl Radical Storm: A Novel Phototherapy Nanoplatform for Potent Ferroptosis\u2011Like Cell Death Induction in Tumors"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-9751-4514","authenticated-orcid":false,"given":"Lie","family":"Li","sequence":"first","affiliation":[{"name":"Biomaterials Research Center School of Biomedical Engineering Southern Medical University  Guangzhou P. 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