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Here, we report carbon dot\u2013functionalized Haversian\u2010mimetic scaffolds designed to combine antibacterial activity with regenerative support in IBDs. A 3D\u2010printed scaffold fabricated by digital light processing is constructed by integrating human hair\u2013derived carbon dots (CrCi\u2010CDs) into a silk fibroin methacrylate (SilMA)\/gelatin methacrylate (GelMA) network, yielding the CrCi\u2010CDs\/SilMA\/GelMA scaffold (CSG). In this biomimetic scaffold, CrCi\u2010CDs provide metabolism\u2010targeted antibacterial activity. Combined transcriptomic and metabolomic analyses indicate that they damage bacterial membranes and interfere with central energy metabolism and key biosynthetic pathways. In parallel, CSG reprograms the inflammatory microenvironment by promoting macrophage polarization toward a pro\u2010healing M2 phenotype, while simultaneously enhancing vascular network formation and osteogenic differentiation of bone marrow mesenchymal stem cells. In a rat model of methicillin\u2010resistant\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    (MRSA)\u2010infected femoral condyle defects, CSG exhibited coordinated antibacterial, immunomodulatory, and pro\u2010regenerative effects, resulting in enhanced bone repair. These findings support the potential of the carbon dot\u2013functionalized Haversian\u2010mimetic scaffold as a promising strategy for infected bone defect repair.\n                  <\/jats:p>","DOI":"10.1002\/adhm.71649","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T05:35:17Z","timestamp":1787722517000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Human Hair\u2013Derived Carbon Dot\u2013Functionalized Scaffolds for Metabolism\u2010Targeted Antibacterial Therapy and Regeneration of Infected Bone Defects"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-9855-6981","authenticated-orcid":false,"given":"Xiaofeng","family":"Shi","sequence":"first","affiliation":[{"name":"Shanghai Key Laboratory of Orthopaedic Implants Department of Orthopedics, Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine  Shanghai P. 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