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A new series of sealants named M\u2010MOF\u201074@Gel (M = Mg, Co, Ni, Cu, Zn) is invented for gastric perforation using a triple\u2010layered design including the exterior antibacterial layer, the middle layer of soft scaffold, and the interior thrombin\u2010like layer. Among these sealants, Zn\u2010MOF\u201074@Gel sealant exhibits excellent biocompatibility near 95%, high efficiency of bacterial clearance (83.9% for\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    , 83.7% for\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    ), strong adhesion (94\u00a0kPa), and fast hemostasis for liver and gastric perforation (60 s for liver, 100 s for gastric perforation). In addition, MOF\u201074@Gel sealant can avoid the residue of MOF powder in trauma, adjust to the tissue shape, and inhibit the penetration of exterior aqueous solution. And the in vivo experiments further demonstrate the long\u2010standing flexibility in gastric perforation with adhesive block, resulting in no obvious leakage in the perforation channel. These enable the rats to successfully survive after surgery without dependence on antibiotics, indicating great potential for MOF\u201074@Gel sealant in gastric perforation hemostasis.\n                  <\/jats:p>","DOI":"10.1002\/adhm.71653","type":"journal-article","created":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T08:14:01Z","timestamp":1787818441000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Tailoring Metal Coordination in MOF\u2010Based Triple\u2010Layered Sealants for Gastric Hemostasis"],"prefix":"10.1002","volume":"15","author":[{"given":"Ruoyun","family":"Zhang","sequence":"first","affiliation":[{"name":"School of Biomedical Engineering and Health, State Key Laboratory of New Textile Materials and Advanced Processing, Hubei Jiangxia Lab Wuhan Textile University Wuhan P. R. 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