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Our results reveal that the agarose content modulates the structural, chemical, physical, and biological properties of hydrogels. Noticeably, the hydrogel containing 3 wt% agarose (GelAgar\u2010GA\u20103) shows optimized characteristics, including superior elastic modulus (186 \u00b1 12\u00a0kPa) and tensile strength (173 \u00b1 12\u00a0kPa), mimicking the mechanical properties of native skin. The swelling ability of this hydrogel is modulated via pH changes. Noticeably, the water absorption capacity of GelAgar\u2010GA\u20103 at pH = 5 is 247 \u00b1 47%, which increases to 327\u00b145% at pH = 9. GelAgar\u2010GA hydrogels also indicate significant coagulation ability, low hemolysis (&lt;5%), and decreased bleeding compared to the control. In vitro studies reveal that GelAgar\u2010GA hydrogel could accelerate the proliferation and migration of fibroblasts and shows significant antibacterial activity, following doxycycline encapsulation (GelAgar\u2010GA\u20103(Dox)). In vivo studies on a rat model also show 99% wound closure in full\u2010thickness wounds treated with GelAgar\u2010GA\u20103(Dox), attributed to the reduced inflammatory response and promoted vascular remodeling, maturation, and collagen deposition, thereby resulting in accelerated wound repair. In summary, these results demonstrate that the GelAgar\u2010GA\u20103(Dox) is a favorable system for wound healing applications.<\/jats:p>","DOI":"10.1002\/adhm.71654","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T04:57:46Z","timestamp":1788325066000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Multifunctional pH\u2010Responsive Gelatin\/Agarose Hydrogels Incorporating Gum Arabic for Wound Repair"],"prefix":"10.1002","volume":"15","author":[{"given":"Z.","family":"Ghasemi","sequence":"first","affiliation":[{"name":"Department of Materials Engineering Isfahan University of Technology Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Mohagheghiyan","sequence":"additional","affiliation":[{"name":"Department of Materials Engineering Isfahan University of Technology Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5782-8007","authenticated-orcid":false,"given":"M.","family":"Kharaziha","sequence":"additional","affiliation":[{"name":"Department of Materials Engineering Isfahan University of Technology Isfahan Iran"},{"name":"Bioengineering Institute of Technology Universitat Internacional de Catalunya St\/ Josep Trueta s\/n, Sant Cugat del Vall\u00e8s Barcelona Spain"},{"name":"Department of Bioengineering Universitat Internacional de Catalunya St\/ Josep Trueta s\/n, Sant Cugat del Vall\u00e8s Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Shokri","sequence":"additional","affiliation":[{"name":"Department of Materials Engineering Isfahan University of Technology Isfahan Iran"},{"name":"Research Center for Advanced Technologies, In Cardiovascular Medicine, Cardiovascular Diseases Research Institute Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. 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