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A major challenge in the development of tissue\u2010engineered vascular grafts (TEVGs) is the mismatch between material degradation and tissue regeneration rates, which is driven by individual variability and leads to failure in mechanical support transition, subsequent graft failure, and impeded clinical translation. Here, we report a functionally separated bilayer SDVG that decouples long\u2010term structural support from early bioactive remodeling. The graft consists of a slowly degradable knitted polylactic acid (PLA) framework that preserves mechanical integrity, and a rapidly remodelable chitosan\/gelatin (CS\/GE) porous phase that promotes cell infiltration and tissue regeneration. By tuning the CS\/GE composition, we identified a balanced remodeling window, in which the 1% CS\/GE\u2010PLA graft achieved favorable permeability, cytocompatibility, hemocompatibility, and mechanical performance. In a rabbit carotid interposition model, this optimized graft maintained 100% patency for 3 months and progressively remodeled into a native vessel\u2010like trilaminar structure with endothelial coverage, smooth muscle organization, and extracellular matrix maturation. This bilayer design provides a strategy to coordinate scaffold degradation with tissue regeneration, enabling stable mechanical support and functional vascular remodeling in small\u2010diameter grafts.<\/jats:p>","DOI":"10.1002\/adhm.71660","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T04:24:06Z","timestamp":1788755046000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Bilayer Vascular Graft With Functionally Separated Structural Support and Bioactive Remodeling for Stable Small\u2010Diameter Artery Repair"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4891-9991","authenticated-orcid":false,"given":"Linlin","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Vascular Surgery, Union Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"},{"name":"State Key Laboratory of New 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