{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T10:52:20Z","timestamp":1791543140362,"version":"4.3.4"},"reference-count":66,"publisher":"Wiley","issue":"37","license":[{"start":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T00:00:00Z","timestamp":1788048000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T00:00:00Z","timestamp":1788048000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HD104619"],"award-info":[{"award-number":["R01HD104619"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Endometriosis (EuE) is a chronic, incurable disease. Due to limited efficacy, high recurrence rates, and serious side effects of current treatments, development of new, targeted, nonhormonal therapies is urgently needed. We previously reported that niclosamide, an FDA\u2010approved anthelmintic drug, attenuates endometriotic lesion growth. We further identified folate receptor\u2010\u03b2 (FR\u03b2)\u2010positive macrophages as contributors to disease progression. Significantly, niclosamide inhibits FR\u03b2\n                    <jats:sup>+<\/jats:sup>\n                    macrophages and reduces inflammation, innervation, and angiogenesis. To develop niclosamide as a nonhormonal and selective immune cell\u2010targeted therapy for EuE, we engineered a folic acid (FA)\u2010conjugated 2\u2010deoxyglucose dendrimer (FA\u20102DG\u2010D) using click chemistry to enable selective FR\u03b2\u2010mediated uptake. Conjugation of niclosamide to FA\u20102DG\u2010D yielded a targeted nanotherapeutic (FA\u20102DG\u2010D\u2010Niclo) with enhanced aqueous solubility, controlled intracellular release, and excellent batch\u2010to\u2010batch reproducibility. In a mouse model of EuE, FA\u20102DG\u2010D demonstrated lesion\u2010specific accumulation and selective internalization by FR\u03b2\n                    <jats:sup>+<\/jats:sup>\n                    macrophages with minimal off\u2010target organ retention. A single intraperitoneal dose of FA\u20102DG\u2010D\u2010Niclo (25 or 50\u00a0mg\/kg\/bw of niclosamide) significantly reduced FR\u03b2\n                    <jats:sup>+<\/jats:sup>\n                    macrophage burden, suppressed lesion number and volume, and markedly improved EuE\u2010associated hyperalgesia at 2 weeks post\u2010treatment. Together, these findings establish FR\u03b2\n                    <jats:sup>+<\/jats:sup>\n                    macrophages as a potential target in EuE and present FA\u20102DG\u2010D\u2010Niclo as a nonhormonal, macrophage\u2010focused nanomedicine for precise and effective endometriosis treatment.\n                  <\/jats:p>","DOI":"10.1002\/adhm.71661","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T06:46:56Z","timestamp":1788158816000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["2\u2010Deoxyglucose Dendrimer\u2010Enabled Niclosamide Delivery to FR\u03b2\u2010Expressing Macrophages Alleviates Endometriosis Progression and Associated Hyperalgesia"],"prefix":"10.1002","volume":"15","author":[{"given":"Anubhav","family":"Dhull","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences College of Pharmacy University of Michigan  Ann Arbor Michigan 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Washington State University  Pullman Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rishi","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences College of Pharmacy University of Michigan  Ann Arbor Michigan USA"},{"name":"Department of Chemistry College of Arts and Sciences Washington State University  Pullman Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth John","family":"Goody","sequence":"additional","affiliation":[{"name":"Department of Chemistry College of Arts and Sciences Washington State University  Pullman Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aqib Iqbal","family":"Dar","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences College of Pharmacy University of Michigan  Ann Arbor Michigan 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