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Immunotherapy has brought new hope to PCa patients, but the immunosuppressive characteristics of PCa cells limit its efficacy. Cuproptosis, which can affect tumorigenesis, therapeutic resistance, and immune modulation has received significant attention recently. However, it is limited by insufficient copper ion (Cu\n                    <jats:sup>2+<\/jats:sup>\n                    ) concentration, hypoxia, and overexpression of glutathione (GSH) in tumors. To overcome these limitations, a targeted nanoplatform (CuS@MYC\u2010PEG\u2010FA) is fabricated to achieve a synergistic cuproptosis and immunotherapy. CuS@MYC\u2010PEG\u2010FA can not only promote reactive oxygen species (ROS) generation and Cu\n                    <jats:sup>2+<\/jats:sup>\n                    release, but also elicit a powerful antitumor immunity response. Meanwhile, the loaded c\u2010MYC inhibitor (MYCMI\u20106) can reduce the expression of glutaminase and subsequently inhibit the generation of GSH, further sensitizing cells to cuproptosis effectively. Notably, cuproptosis combined with photothermal therapy (PTT) can turn the \u201ccold\u201d tumor properties of PCa into \u201chot\u201d ones, leading to its sensitivity to anti\u2010programmed death ligand 1 (anti\u2010PD\u2010L1) immunotherapy. The results show that the combination of CuS@MYC\u2010PEG\u2010FA and PD\u2010L1 inhibitor treatment can significantly inhibit the development of PCa, providing a new strategy for the treatment of PCa.\n                  <\/jats:p>","DOI":"10.1002\/adhm.71662","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T03:37:51Z","timestamp":1788320271000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["MYC\u2010Sensitized Cuproptosis Combined With PTT to Remodel the Immune Microenvironment of Prostate Cancer"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3295-5755","authenticated-orcid":false,"given":"Yan","family":"Gao","sequence":"first","affiliation":[{"name":"School of Chemical Science and Engineering Department of Laboratory Medicine Shanghai Tenth People's Hospital of Tongji University Tongji University  Shanghai 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